摘要
目的观察低分子肝素（法安明）对慢性心力衰竭（心衰）患者凝血功能及心功能的影响。方法98例慢性心衰患者（NYHA分级Ⅱ～Ⅳ级）随机分成2组,治疗组（49例）和对照组（49例）。对照组给予强心、利尿、扩血管治疗,治疗组在此基础上加用低分子肝素5000 U/次皮下注射,2次/d共1个月。治疗后检查心脏超声,评估心功能,测定血浆D-二聚体,血浆纤维蛋白原水平。结果1个月后治疗组血浆D-二聚体,血浆纤维蛋白原水平明显降低（P〈0.01）。心功能按NYHA分级治疗组与对照组比较有明显改善（P〈0.01）,左室射血分数有明显提高（P〈0.01）。结论低分子肝素能降低血浆D-二聚体,血浆纤维蛋白原水平,改善心脏功能,有益于慢性心衰的治疗。
Objective To observe the effects of low molecular weight heparin on cardiac function and coagulation function of patients with chronic heart failure. Methods 98 patients with chronic heart failure（NYHA Grade Ⅱ - Ⅳ ） were randomly divided into two groups. 49 patients in control group were treated by cardiac, diuretic and dilating vessels, while the other 49 patients in treatment group, on the therapeutic basis of control group, were treated with low molecular weight heparin 5000 U once, twice a day for 1 month. One month after treatment, the levels of plasma fibrin D-dimer and fibrinngen were tested and cardiac function were detected by echocardiogram. Results One month after treatment, the levels of plasma fibrin D-dimer and fibrinogen were obviously decreased in treatment group, as compared with those of control group（ P 〈 0.01 ）. At the same time, the cardiac function （NYHA Grade Ⅱ-Ⅳ ） in treatment group was significantly improved, as compared with that of control group（ P 〈 0.01 ）, and left ventricular ejection fraction in treatment group was obviously increased （ P 〈 0.01 ）. Conclusion The low molecular weight heparin can improve cardiac function, reduce levels of plasma fibrin D-dimer and fibrinogen, which is helpful to treat chronic heart failure.
出处
《河北医药》
CAS
2009年第1期29-30,共2页
Hebei Medical Journal
关键词
肝素
低分子量
心力衰竭
充血性
心功能
凝血功能
low molecular weight heparin
chronic heart failure
cardiac function
coagulation function
