摘要
In vitro bioassay screening systemically,we find that the crude extract of mangrove endophytic fungus Paecilomyces sp.(tree1-7)from the Taiwan Strait showed strong inhibiting to KB cells,and isolate three isomeric compounds,secalonic acid A(1),penicillixanthone A(2),paecilin A(3).Their structures are elucidated by spectral data,and the 3 is the first time to be isolated from marine fungus.The results of primary bioactivity experiments indicate that the three compounds display strong inhibiting activity to KB cell in vitro,and 1 show inhibiting to KB and KBv cells at IC50 less 1.57nmol/mL,2 at IC50 less 1.22nmol/mL and 3 at IC50 40,50nmol/mL,respectively.
In vitro bioassay screening systemically, we find that the crude extract of mangrove endophytic fungus Paecilomyces sp. （treel -7 ）from the Taiwan Strait showed strong inhibiting to KB cells, and isolate three isomeric compounds, secalonic acid A （1）, peniciUixanthone A（2）, paecilin A（3 ）. Their structures are elucidated by spectral data, and the 3 is the first time to be isolated from marine fungus. The results of primary bioactivity experiments indicate that the three compounds display strong inhibiting activity to KB cell in vitro,and 1 show inhibiting to KB and KBv cells at IC5o less 1.57nmol/mL,2 at ICs0 less 1.22nmol/mL and 3 at IC5040,50nmol/mL, respectively.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2009年第2期198-202,共5页
Chemical Research and Application
基金
国家863计划(2006AA09Z422
2006AA09Z419)资助
国家自然科学基金(20572136)资助
广东药学院博士启运基金资助项目
