摘要
目的和方法为探讨急性脑梗死不同时期一氧化氮（NO）含量变化的临床意义，送检42例急性脑梗死患者不同时期的血清，采用Green改良法检测NO和以邻苯三酚自氧化法检测超氧化物歧化酶（SOD）含量，并配有30例正常对照。结果结果表明：脑梗死早期NO、SOD含量显著降低；急性期NO含量增高，并超过正常对照，而SOD含量进一步下降；脑梗死稳定期后，NO含量有所下降，接近正常水平，SOD含量增高，但仍低于正常。结论据上述结果提示，NO在急性脑梗死不同时期具有细胞毒性和组织保护双重作用，为临床寻求一种急性脑梗死的可能有效治疗方法提供了理论依据。
Objective In order to study the clinical significance of assaying Nitric Oxide content indifferent periods of acute cerebral infarction. Methods An improved Green andAutoxidation of Pyrogallol were used to measure NO and SOD content in the serum of acutecerebral infarction which totaled 42 cases, while 30 cases of health persons were testedsimilarly as the control group. Results The results showed that the activity of NO and SODdecreased dramatically in the early period. No content in the serum of cerebral infarction inacute stage was higher than that of the control group. While SOD content decreasedcontinuously. NO content in convalescent stage was lower, but it was almost within normallevel. SOD content raised and it was lower than that of the control group. Conclusion Weevaluated that NO played a cell-toxic and tissue-protective dual efficacy in different periodsof acute cerebral infarction and provided theoretical basis for managing acute cerebralinfarction in clinical practice.
出处
《中国神经免疫学和神经病学杂志》
CAS
1998年第1期21-23,共3页
Chinese Journal of Neuroimmunology and Neurology
关键词
一氧化氮
脑梗死
急性
临床
nitric oxide
superoxide dismutase
cerebral infarction
