摘要
目的:研究侵袭性牙周炎(aggressive periodontitis,AgP)患者抗牙龈卟啉单胞菌(porphyromonas gingivalis,Pg)的IgG抗体滴度与疾病程度、性别、年龄和吸烟的关系。方法:(1)AgP患者91人,其中男35人,女56人,平均27.6岁,吸烟者14人。牙周健康者35人,男10人,女25人,平均29.4岁。(2)问卷调查吸烟状况、全口根尖片评价牙槽骨吸收状况。(3)根据中、重度牙槽骨吸收的牙数,分为重度AgP组58人,轻-中度组33人。(4)采用ELISA法测定血清中抗Pg的IgG抗体滴度。结果:(1)AgP组血清中抗Pg的IgG抗体滴度的光密度值(8.55±3.24)明显高于健康组(4.78±2.58,P=0.000 4);(2)男、女组Pg的IgG抗体水平分别为8.38±3.73和8.67±2.90,差异无统计学意义。(3)年轻组(≤25岁)抗体滴度(6.96±3.98)明显低于年长组(9.26±2.58,P=0.001 4)。(4)吸烟组Pg的IgG抗体滴度(7.33±3.72)明显低于非吸烟组(8.78±3.12,P=0.016)。(5)重度AgP组抗Pg的IgG抗体滴度(9.33±2.59)明显高于轻-中度组(7.19±3.80,P=0.002)。结论:多因素分析显示AgP患者抗Pg的IgG抗体水平与吸烟(OR=1.039)、年龄(OR=1.157)和病变程度(OR=1.132)有关。
Objective：To measure the anti-Pg（ porphyromonas gingivalis, Pg）IgG antibody titers in serum in patients with aggressive periodontitis （AgP） ; to study the association of IgG titers with periodontal status （ alveolar bone loss） ; to analyze the age, gender or smoking status on lgG levels in patients with aggressive periodontitis. Methods： （ 1 ） Ninety-one AgP subjects with an average age of 27.6 years （ females 56, males 35, and 14 male-smokers） were collected. Thirty-five healthy subjects with an average age of 29.4 years （ males 10 and females 25） were also collected as control group. （2） Questionnaire, clinical evaluations and assessments of alveolar bone loss were made. （3） Patients were categorized into two groups： severe AgP group （58 subjects, with 〉 14 teeth of moderate-severe alveolar bone loss） ; light-moderate group （33 subjects）. （4） To collect serum sample of patients and determine the anti-Pg IgG antibody titers in serum using ELISA. Results： （ 1 ） The mean IgG antibody titers to Pg in AgP group （8.55 ±3.24） were significantly higher than that in control group （4. 78 ±2. 58 ,P =0. 000 4）. （2） No significant difference [ （8.38 ±3.73） and （8.67 ±2. 90）, respectively] of mean anti-Pg IgG titers was found between male and female. （ 3 ） The mean of anti-Pg IgG titers （ 9.26 ± 2.58 ） in elder group （ aged 〉 25 ） was significantly higher than that in younger patients （ 6.96 ± 3.98, P = 0. 001 4 ）. （4） Smokers had significantly lower anti-Pg IgG titers （7.33± 3.72） than non-smokers （8.78 ± 3.12,P = 0. 016）. （5） Anti-Pg IgG titers in severe AgP group was significantly higher than that in light-moderate AgP group. （6）The results of multi-factor regression analysis showed that smoking, age and status of alveolar bone loss were the factors affecting anti-Pg IgG titers. Conclusion： The titers of IgG antibody to Pg in serum were related to age, smoking and periodontal status in AgP patients.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2009年第1期52-55,共4页
Journal of Peking University:Health Sciences
基金
国家自然科学基金项目(30471882)
教育部教育振兴行动计划特殊专项("九八五"工程)
"十一五"国家科技支撑计划(2007BAZ18B02)项目资助~~
关键词
牙周炎
紫单胞菌
龈
免疫球蛋白G
抗体生成
Periodontitis
Porphyromonas gingivalis
Immunoglobulin G
Antibody formation
