摘要
目的：探讨幽门螺杆菌（Ｈｐ）感染对胃粘膜白细胞介素６（ＩＬ６）和肿瘤坏死因子（ＴＮＦ）产生的影响及ＩＬ６和ＴＮＦα在Ｈｐ相关性胃炎发病机理中的作用。方法：用生物活性法和放免法检测慢性胃炎患者粘膜体外培养２４小时后ＩＬ６和ＴＮＦα的水平。结果：Ｈｐ阳性胃炎患者胃窦ＩＬ６活性和ＴＮＦα含量均明显高于Ｈｐ阴性的患者和正常对照组；且ＩＬ６活性和ＴＮＦα含量呈正相关。合并活动性胃炎者胃窦ＴＮＦα含量也明显高于非活动性胃炎，但两者胃窦ＩＬ６活性却没有明显的差异。结论：Ｈｐ感染可诱导胃粘膜的炎症细胞合成和释放ＩＬ６和ＴＮＦα。
Aim: To study the effect of Helicobacter pylori (Hp) infection on the production of antral mucosal interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) and the roles of IL-6 and TNF-α in the pathogenesis of Hp gastritis. Methods: Bioactivity assayand radioimmunoassay were used to measure the production of LI-6 and TNF-α by antral mucosa of patients with chronic gastritis during 24 hours culture in vitro Results: Antral IL-6 activity and TNF-α content in patients with Hp infection were signicantly greater than that in patients without Hp infection and normal controls, there was a significant correlation between IL-6 and TNFα;TNFα contents were significantly higher in those with active gastritis than in those with inactive gastritis,in contrast,IL-6 activity were raised in both active and inactive gastritis. Conclusions: Antral mucosal production of IL-6 and TNF-α may be induced by Hp infection; Hp gastritis may be associated with increased gastric mucosal production of IL-6 and TNFα
出处
《胃肠病学和肝病学杂志》
CAS
1998年第1期42-44,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
幽门螺杆菌
白细胞介素6
肿瘤坏死因子
胃炎
Helicobacter pylori Interlenkin-6 Tumor necrosis factor-α Gastric mucosa
