摘要
目的：了解球样异型增生细胞的癌前意义。方法：应用ＣＭＩＡＳ－００７型图象分析系统检测３４例胃印戒细胞癌、４４例球样异型增生细胞和１５例正常胃粘膜上皮细胞的ＤＮＡ含量。结果：胃印戒细胞癌、球样异型增生细胞和正常胃粘膜之间ＤＮＡ含量差异有显著性（Ｐ＜０．０５及Ｐ＜０．０１）。直方图上，正常胃粘膜细胞呈位于２Ｃ区的单峰型。胃印戒细胞癌的众数峰右移，分布分散，各例都有＞５Ｃ的非整倍体细胞出现。球样异型增生细胞的图象介于两者之间，其中Ⅲ级球样异型增生细胞含有＞５Ｃ的非整倍体细胞。结论：球样异型增生细胞是一种异常增生细胞，是胃印戒细胞癌的癌前病变。
Purpose To understand precancerous significance of globoid dysplasia cells. Methods Cellular nuclear DNA content was measured by CMIAS007 image analysis system in 34 cases of gastric signetring cell carcinoma (SCC) and 44 cases globoid dysplasia cells (GDC) in the pareneoplastic tissue, as well as in 15 cases of normal gastric specimens. Results The mean DNA value increased significantly from normal gastric mucus membrane, GDC to SCC (P<005). In histograms, normal gastric tissue showed a singlepeak type located at 2C. SCC showed lower multipeaks which migrated to 4C and spread widely with more aneuploid (>5C) cells. The histograms of GDC was between normal tissue and SCC, and there were also some aneuploid cells in Ⅲ grade GDC. Conclusions These results suggest that GDC may be an abnormal proliferating cell and a precancerous lesion of SCC.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第2期146-148,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
胃肿瘤
印戒细胞癌
球样异型增生
DNA
stomach neoplasms
carcinoma, signet ring cell
precancerous conditions
globoid dysplasia cell
gastric mucosa
DNA
