摘要
目的探讨人类膜性肾炎的致病因素及防治。方法选用被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）动物模型，定期观察实验大鼠血清、肾组织中超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量的变化及还原型谷胱甘肽（ＲＧＴ）对它们的影响。结果ＰＨＮ组实验４周、８周，ＳＯＤ活性显著下降，ＭＤＡ含量明显上升，给ＲＧＴ处理后能显著减少ＭＤＡ的含量，减轻大鼠的蛋白尿，但对ＳＯＤ作用不著。结论ＰＨＮ的大鼠机体清除氧自由基能力下降，肾组织发生脂质过氧化为其损伤的因素之一。ＲＧＴ能减少肾脂质过氧化，减轻组织的病理损伤。
Objective To investigate the pathogenetic factor, prevention and treatment of human membranous nephritis.Methods The passive Heymann nephritis (PHN) was used in this experiment. The changes of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and renal tissue of PHN rats and the effects of reduced glutathione (RGT) on them were studied.Results It was found that the SOD activity was reduced and the MDA levels were elevated remarkably 4 and 8 weeks after injecting Heymann antibody into the rats. RGT could reduce the MDA contents and urine protein in PHN rats, though having no obvious effects on SOD.Conclusion The rats with PHN have decreased ability to clear free radicals. The renal tissue lipid peroxidation is a pathogenetic factor of PHN and RGT can reduce the lipid peroxidation as well as the injury of renal tissue in PHN rats.
出处
《徐州医学院学报》
CAS
1998年第3期188-191,共4页
Acta Academiae Medicinae Xuzhou
