摘要
目的分析2007年夏季吉林省长春市双阳区群发吉兰-巴雷综合征（Guillmn—Barre syndrome，GBS）的病例特点。方法22例GBS患者均行血清病原学、乙肝两对半、空肠弯曲菌的培养及神经电生理检查。结果22例GBS患者中男12例，女10例，均集中在2007年6-7月的2周内发病，全部患者病前均饮用过生水，17例有病前感染史，16例病前曾有腹泻，1例曾有上呼吸道感染史，1例腹泻合并上呼吸道感染。所有患者均以四肢无力为首发症状，8例伴有客观的感觉障碍，5例出现脑神经受累、呼吸困难及咳痰力弱，3例气管切开行呼吸机辅助通气。粪便空肠弯曲菌培养1例为阳性。11例患者脑脊液蛋白升高[（0．74±0．32）g/L]，细胞数平均为3×10^6／L；血清中乙肝病毒3种抗体均阳性者17例，12例患者的神经电生理检查出现运动神经波幅降低，感觉神经不受累。结论长春市双阳区群发GBS22例中有12例符合急性运动轴索型，与以往的群发报道相似。
Objective To clearify the features of an outbreak of Guillain-Barr6 syndrome （GBS） from Shuangyang district of Changchun city, Jilin province, China. Methods Serum samples obtained were tested serologically for antibodies to chlamydia, coxsackie virus, cytomegalovirus, and hepatitis B virus. Stool samples obtained were cultivated to search Campylobacter jejuni. Electrodiagnostic studies were done 1 day after onset to 10 days. Results Twenty-two patients （ 12 males and 10 females, aged 15-71 years） were from Shuangyang district, a suburb of Changchun, during a 2-week period in June to July 2007. An illness in the preceding 4 weeks was reported in 17 patients, 16 gave a history of diarrhoea, 1 patient had symptoms consistent with an ＂upper respiratory infection＂ and 1 patient had both. Limb weakness were the earliest symptoms. Respiratory assistance was needed by 3 patients. Tendon reflexes were lost as weakness developed. Eleven patients had raised concentrations of protein in the cerebrospinal fluid （ （0.74 ±0.32） g/L）, and the averaged cell count was 3 ×10^6/L. There were 3 kinds of antibodies of hepatitis B virus positive above 17 GBS patients. Electrodiagnostic studies showed severe reductions in motor evoked amplitudes from distal stimulation in 12 patients. Sensory action potentials were normal. Conclusions The distinctive epidemiological, clinical and electromyography characteristics of these patients suggest that the disorder, different from acute inflammatory demyelinating polyneuropathy, is concordant with acute motor axonal neuropathy. The features of Shuangyang GBS was similar to those previously reported in several aspects.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2009年第1期30-33,共4页
Chinese Journal of Neurology
