摘要
采用试管双倍稀释法，选用部分临床分离致病菌和标准菌株，对罗红霉素胶囊进行了体内外抗菌作用实验．体外抗菌实验结果表明：本品对金黄色葡萄球菌、表皮葡萄球菌、链球菌、流感杆菌等的ＭＩＣ５０分别为：０．１９５，０．６２５，０．７８，０．３９ｍｇ／Ｌ；考察了不同细菌接种量、培养基中血清浓度、培养基的不同ｐＨ值等对罗红霉素体外抗菌作用的影响．体内的保护实验结果表明：本品对接种金黄色葡萄球菌的小鼠口服给药的ＥＤ５０为５．６６ｍｇ／ｋｇ，对接种肺炎链球菌的小鼠口服给药的ＥＤ５０为１７．７７ｍｇ／ｋｇ．
The paper described invitro and invivo antibacterial activities of Roxithromycin capsules against some clinical strains and standard strains by using the tube double dilution method.In invitro antibacterial experiment,MIC50 against S.aureus,S.epidermidis,Streptococcus,Hinfluenzas were 0195,0625,078,039 mg/L.Influences of changes of inoculation quantity,serum concentration in media and pH of media on invitro antibacterial activity(MIC50) were also studied.In the invivo protection experiment,ED50 on mice of Roxithromycin Capsules after oral administration against S.aureus,Streptococcus pneumoniae were 566 mg/kg,177 mg/kg.
出处
《沈阳药科大学学报》
CAS
CSCD
1998年第2期112-115,共4页
Journal of Shenyang Pharmaceutical University
关键词
罗红霉素
抗菌作用
胶囊剂
roxithromycin
antibacterial activity
capsule
