摘要
目的观察白芷香豆素组分(TCD)对家兔氨茶碱药动学的影响。方法取家兔9只,采用自身对照法。静脉注射氨茶碱15.0 mg.kg-1,6 d后灌胃给予TCD 50.0 mg.kg-1,qd,共3 d,末次给药1 h后静脉注射氨茶碱,15.0 mg.kg-1,紫外分光光度法测定血清茶碱浓度。结果给予TCD前、后茶碱的K分别为0.213和0.139 h-1;t1/2分别为3.253和4.993 h;Vd分别为1.416和1.437 L;CL分别为0.302和0.200 L.h-1;AUC分别为134.322和202.968μg.h.mL-1。结论TCD能抑制氨茶碱在兔体内的代谢,使K降低,t1/2延长,AUC增大,CL下降。
Objective To study the effect of total coumarins from Radix Angelicae Dahurica （TCD） on pharmacokinetics of aminophylline in rabbits. Methods A self-controlled method was used. 9 rabbits were intravenously injected with aminophylline 15.0 mg · kg^-1. After 6 days, the rabbits were orally administered with TCD 50.0 mg·kg^-1 , qd, for 3 days, and then given animophylline 15.0 mg·kg^-1 again. The serum concentrations of theophylline were determined with spectrophotometer. Results Before TCD administration, elimination rate constant （K）, half life （t1/2 ）, apparent volume of distribution（Vd） ,clearance（CL） and area under curve（AUC） of theophylline were 0. 213 h^-1, 3. 253 h, 1. 416 L, 0. 302 L·h^-1 and 134. 322 μg·h^-1 mLa respectively. After TCD administration, K, t1/2, Vd, CL and AUC were 0. 139 h^-1 , 4. 993 h, 1. 437 L, 0.200 L·h^-1 and 202. 968 μg·h6-1 mL^-1 respectively. Conclusion The serum concentrations and A UC of theophylline were significantly increased, t1/2 prolonged, K and CL decreased in the rabbits after administered with TCD. It is concluded that TCD inhibits the normal metabolism of theophylline.
出处
《医药导报》
CAS
2009年第2期162-164,共3页
Herald of Medicine
关键词
白芷香豆素
氨茶碱
茶碱
相互作用
药动学
Coumarins from radix angelicae dahuricae
Aminophylline
Theophylline
Interaction
Pharmacokinetics
