摘要
合成了２－氯代苯甲醛丙氨酸钾席夫碱（Ｃ１０Ｈ９ＣＩＮＯ２Ｋ·Ｈ２Ｏ，简写为２－ＣＡＫ）及其Ｃｕ（Ⅱ）、Ｚｎ（Ⅱ）、Ｃｏ（Ⅱ）、Ｎｉ（Ⅱ）金属配合物［Ｃｕ（２－ＣＡ）２］（Ｃ２０Ｈ１８Ｃｌ２Ｎ２Ｏ４Ｃｕ·２Ｈ２Ｏ）、［Ｚｎ（２－ＣＡ）２］（Ｃ２０Ｈ１８Ｃｌ２Ｎ２Ｏ４Ｚｎ·４Ｈ２Ｏ）、［Ｃｏ（２－ＣＡ）２］（Ｃ２０Ｈ１８Ｃｌ２Ｎ２Ｏ４Ｃｏ·Ｈ２Ｏ）、［Ｎｉ（２－ＣＡ）２］（Ｃ２０Ｈ１８Ｃｌ２Ｎ２Ｏ４Ｎｉ·２Ｈ２Ｏ），并用电子吸收光谱、荧光光谱、表面增强拉曼光谱研究了它们与ＤＮＡ的相互作用。初步探讨了它们与ＤＮＡ的作用方式，２－ＣＡＣｏ、２－ＣＡＺｎ是两种值得进一步研究的可能抗癌药物，它们与ＤＮＡ作用采取两种不同的方式。
Schiff base, which derived from 2chlorobenzaldehyde and alanine (C10H9ClNO2K·H2O, 2CAK), and its Cu(Ⅱ), Zn(Ⅱ), Co(Ⅱ), Ni(Ⅱ) complexes ([Cu(2CA)2](C20H18Cl2N2O4Cu·2H2O), [Zn(2CA)2](C20H18Cl2N2O4Zn·4H2O), [Co(2CA)2](C20H18Cl2N2O4Co·H2O), [Ni(2CA)2](C20H18Cl2N2O4Ni·2H2O) have been synthesized for the first time. The effects of these compounds on DNA have been studied by the UVVis, Fluorescence and SERS spectra method. The significant increase and shiftiness in intensity and wavenumbers of 2CAZn upon binding to DNA is attributed to the formation of a simple 2CAZnDNA complex. The results show that 2CACo、 2CAZn have strong interactions with DNA. Their acting ways on DNA are different. It is worthy to do a further research on these compounds as anticancer drugs.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
1998年第1期84-91,共8页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金
关键词
席夫碱
配合物
2-CAK
CAK
DNA
抗癌药
Shiff base and their complex DNA\ \ \ fluorescence spectrumsurfaceenhanced Raman spectrum
