摘要
目的探讨nm23与Ki-67、ToPoⅡ在消化道腺癌中的表达情况。方法用Envision免疫组织化学方法检测nm23与Ki-67、ToPoⅡ在消化道89例腺癌中的表达,并对结果进行判断分析。结果nm23总阳性率为95.5%(85/89),高-中分化癌阳性率93.8%(60/64),低分化癌阳性率为100%。Ki-67总阳性率为91.0%(84/89),高-中分化癌阳性率92.1%(59/64),低分化癌阳性率为88.0%(22/25)。ToPoⅡ总阳性率为84.3%(75/89),高-中分化癌阳性率81.2%(52/64),低分化癌阳性率为92.0%(23/25)。nm23与Ki-67有负相关性,随nm23阳性强度的增加,Ki-67阳性强度降低(P<0.05)。nm23与ToPoⅡ无相关性(P>0.05)。结论nm23与Ki-67呈负相关,与ToPoⅡ无相关性。
Objective To study the expressions of nm23 Ki-67 and ToPo Ⅱ in gastrointestinal adenocarcinoma. Methods The expressions of nm23 Ki-67 and ToPo Ⅱ was detected in 89 gastrointestinal adenocarcinoma by immunohistochemical Envision method and the expression relationship of nm23 and Ki-67 and ToPo II was analyzed. Results The nm23 total positive rate was 95.5% （85/89）, positive rate in median and high differentiation group was 93.8% （60/64）, positive rate in low differentiation group was 100%. The Ki.67 total positive rate was 91.0% （81/89） ,positive rate in median and high differentiation group was 92. 1% （ 59/64）, positive rate in low differentiation group was 88.0% （22/25）. The ToPo Ⅱ total positive rate was 84. 2% （85/89）, positive rate in median and high differentiation group was 81.25% （52/64）, positive rate in low differentiation group was 92. 0% （ 23/25 ）. Negative correlation existed between the expressions of nm23 and Ki -67 （ P 〈0. 05 ）. But there was no correlation between nm23 and ToPo Ⅱ（P 〉0. 05 ）. Conclusion Negative correlation existed between the expressions of nm23 and Ki.67. But there was no correlation between nrn23 and ToPo Ⅱ.
出处
《临床合理用药杂志》
2009年第1期18-19,共2页
Chinese Journal of Clinical Rational Drug Use
