摘要
用ABC法对10例胃肠道腺癌和癌旁组织中12种凝集素受体进行了组织化学研究。结果表明:胃癌中表达的凝集素受体的种类要多于大肠癌;而Glc/Man和GlcNAc特异性的凝集素受体的阳性率高于Gal/GalNAC和Fuc特异性的凝集素受体。从胃到直肠,胃肠道癌旁组织中凝集素受体谱从胃型逐步变迁成直肠型。胃肠道癌中凝集素受体的表达与其癌旁组织有明显不同。癌组织中凝集素受体表达水平的增高和降低、某些受体的出现和消失以及受体分布的改变,间接地受细胞基因的调节。
Ten cases of gastrointestinal adenocarcinomas were histochemically investigated for their lectin receptors by avidin-biotin-peroxidase complex (ABC) method. Results showed that gastric adenocarcinomas expressed more types of lectin receptors than large bowel adenocarcinomas. Positive rates of G1c/Man-and GlcNAc-specific lectin receptors in those tumors were higher than those of Gal/GalNAc- and Fuc-specific lectin receptoes. From the stomach to rectum, the spectrum of the lectin receptors in pericarcinomatous tissues gradually changed from the gastric type to rectal type. The expression of lectin receptors in gastrointestinal adenocarcinomas was obviously different from that in their corresponding pericarcinomatous tissues. The increase and decrease of lectin receptor expression, the appearance and disappearance of some types of lectin receptors as well as the change of the receptor distribution are indirectly regulated by cellular genome.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第6期519-523,共5页
Academic Journal of Second Military Medical University
关键词
凝集素受体
胃肿瘤
胃肠道腺癌
expression of lectin receptors
histochemistry
glycoconjugates
gastrointestine
adenocarcinoma
