摘要
应用ＡＢＣ免疫组织化学染色方法检测１２０例胃癌和大肠癌的癌肿内及转移淋巴结中ｃ－ｅｒｂＢ－２、ｐ５３、ｐ２１基因的过度表达。多基因阳性在胃癌中占６６．７％；大肠癌中占６８．３％，多基因表达明显提示胃癌及大肠癌预后差。单基因阳性亦分别显示胃癌及大肠癌预后较差。转移淋巴结与胃癌及大肠癌的原发癌肿之间基因过度表达与否的平均符合率ｃ－ｅｒｂＢ－２为８３．１％；ｐ５３为７５．３％；ｐ２１为７７．９％，表明转移淋巴结中的基因过度表达与否与原发癌肿相似。ｃ－ｅｒｂＢ－２、ｐ５３、ｐ２１的多基因表达的检测对胃癌和大肠癌的预后判断明显优于其中某个单基因表达的检测。
The overexpression of cerbB2,p53 and p21 in 120 cases of gastric and colorectal cancers and their metastatic lymph nodes were studied immunohistochemically.The multiple gene positive rate in gastric cancer was 66.7% and that in colorectal cancer was 68.3%.The polygene overexpression significantly indicated poor prognosis of gastric and colorectal cancers,just as anyone single gene overexpression.The mean coincident rates of overexpression or nonoverexpression of cerbB2,p53,p21 in metastatic lymph nodes and the primary gastric and colorectal cancers were 83.1%,75.3% and 77.9% respectively which means that overexpression in metastatic lymph nodes paralleled that in the primary tumors.Determination of overexpression of cerbB2,p53 and p21 simultaneously was superior that of any one gene singly in evaluating the prognosis of gastric and colorectal cancers.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第4期296-298,共3页
Chinese Journal of Clinical Oncology
关键词
胃癌
大肠癌
肿瘤基因
基因表达
预后
Gastric cancer Colorectal cancer Oncogene PrognosisGene expression
