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原发性肝癌病人血清白细胞介素6含量的观察 被引量:3

Study on interleukin6 level in hepatic carcinoma and relation to clinical features
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摘要 本实验应用ELISA方法检测原发性肝癌(PHC)病人血清中白细胞介素6(IL-6)含量,探讨了IL-6含量与肝癌病情的关系。结果表明:1.IL-6在PHC病人组明显高于肝硬化(LC)组和对照组:2.IL-6与AFP含量呈正相关;3.IL-6在肿瘤直径大于5cm单发组,明显高于直径小于5cm单发组;4.肝内转移组,又明显高于无肝内转移组。 The serum level of IL-6 has been examined by ELISA in patients with hepatic carcinoma.The results show that:1.The level of IL-6 in hepatic carcinoma is higher than that in the cirrhosis and control.2.The level of IL-6 have positive relation to AFP level.3.The level in transfer class is higher than in no transfer class.We can conclude that IL-6 level correlate closely with pathogenesy of hepatic carcinoma.It is suggested that IL-6 may be a tumor sign and it can indicated clinical featurs.
机构地区 吉林化工医院
出处 《临床肝胆病杂志》 CAS 北大核心 1998年第2期119-120,共2页 Journal of Clinical Hepatology
关键词 原发性 肝癌 白细胞介素6 血清 IL-6 Hepatic carcinoma AFP.
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参考文献5

  • 1Yeqing Sun,katsutoshi tokushige,Etsuko et al.Elevated serum interleukin-6 levels in patients with acute hepatitis.J Clin.Immunoligy 1992.12:197.
  • 2Lumsden AB.Henderson M.Kutner MH.Endotoxin levels measured by a chromogenic assay in portal,hepatic and peripheral venous blood in patients with cirrhosis.Hepatology.1988.8:232.
  • 3Deviere J.Content J.Dengs C,et al.High interleukin-6 serum levels and increased production by leukocytes in alcoholic liver citrhosis:correlation with IgA serum Ievels and lymphokines production Clin.J.Exp.Med.1987.165:194.
  • 4Haruhirl Nakazaki MD.Preoperative and postoperative cytokines in patients with cancer.Cancer.1990.70:709-713.
  • 5Nakazaki.Effects of cytokines on autocrine growth of established hepatoma cell lines.Hepatology 1991.15:231.

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