摘要
本文通过直接肝内注射及静脉滴注促肝细胞生长素（ＰＨＧＦ）两种方法治疗慢性乙型肝炎患者２６例，比较两者对肝炎组织活动性指数（ＨＡＩ）及肝纤维化指数（ＨＦＩ）的影响。结果治疗后，直接肝内注射组的ＨＡＩ及ＨＦＩ均显著低于治疗前（Ｐ＜０．００１），并显著低于静脉给药组的ＨＡＩ及ＨＦＩ（Ｐ＜０．００１）；静脉给药组的ＨＡＩ显著低于治疗前（Ｐ＜０．０５），ＨＦＩ与治疗前无显著性差异（Ｐ＞０．０５）。结论：直接肝内注射ＰＨＧＦ在短期内即可显著改善慢性乙肝肝组织的炎症反应及纤维化程度，且经两次以上肝活组织检查随访。
This paper observed the effects of intrahepatic injection and intravenous drip with PHGF on HAI and HFI of the liver of patients with chronic hepatitis B.The results showed that in the intrahepatic injection group,HAI and HFI were lower significantly than those in intravenous drip group (P<0001,P<001);in the intravenouse drip group,HAI was reduced obviousely(P<005),but HFI was not improved significantly(P>005)after treatmemt.The conclusion is that the inflammation and fibrosis of the liver of patients with chronic hepatitis B are improved significantly in short period by intrahepatic injection with PHGF,and the followup study on the liver tissues comfirms curative effect to be reliable and lasting.
出处
《临床肝胆病杂志》
CAS
北大核心
1998年第2期87-89,共3页
Journal of Clinical Hepatology
