摘要
微波辐射条件下,以丙酮作溶剂,1-[二-(4-氟苯)甲基]哌嗪与氯乙酸乙酯反应得到2-[二-(4-氟苯)甲基]哌嗪乙酸乙酯(1),1与水合肼在微波辐射条件下反应得到2-[二-(4-氟苯)甲基]哌嗪乙酰肼(2),进一步在微波辐射条件下由2-[二-(4-氟苯)甲基]哌嗪乙酰肼(2)与取代芳香醛反应制得目标化合物3a～3f.合成的6个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证.
Six new 2-[4-bi-（4-fluorophenyl）-methylpiperazin-l-yl] acteyl hydrazones 3a-3f were synthesized. Under microwave irradiation conditions, 1-[bi-（4-fluorophenyl）methyl]-piperazine was reacted with ethyl chloroacetate in acetone to form ethyl 2-[4-bi-（4-fluorophenyl）-methylpiperazin-l-yl]acetate （1）. Compoun 1 was reacted with hydrazine to give 2-[4-bi-（4-fluorophenyl）-methylpiperazin-l-yl]acteyl hydrazine （2） under microwave irradiation conditions. Treatment of the compound 2 with aromatic aldehydes under microwave irradiation yielded the corresponding compounds 2-[4-bi-（4-fluorophenyl）methylpiperazin-l-yl] acteyl hydrazones 3a-3f with good yields. The structures of the six new compounds were confirmed by IR, ^1H NMR, MS techniques and elemental analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第1期119-122,共4页
Chinese Journal of Organic Chemistry
基金
西南民族大学青年重点基金(No.08NQZ002)资助项目
