摘要
以环己酮与4-硝基苯甲醛直接不对称Aldol缩合为模型反应,对一系列具有C2对称性的有机小分子催化剂进行了考察,其中(2S,5S)-吡咯烷-2,5-二羧酸的不对称催化效果最好.在10℃下,以DMSO为溶剂,30%摩尔分数催化剂用量,研究了多个取代芳香醛和环己酮的不对称催化Aldol反应,对映选择性为87%～99%ee.
Several C2 symmetric molecules were tested as organocatalysts for the direct catalytic asymmetric aldol reaction of cyclohexanone with 4-nitrobenzaldehyde. （2S,5S）-Pyrrolidine-2,5-dicarboxylic acid afforded the best results for this transformation. The reaction of a series of aromatic aldehydes with cyclohexanone was carried out in DMSO using a catalyst loading of 30 mol% at 10 ℃, and the aldol adducts were obtained in 87%-99% ee.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第8期1416-1422,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20402004)
上海市自然科学基金(No.06ZR14028)资助项目
