摘要
目的探讨凝血与纤溶指标的动态变化在产科弥漫性血管内凝血(DIC)诊断中的意义。方法对健康非孕妇和健康产妇的产前状态及发生DIC的产妇的产前状态和产程状态的标本各50例进行凝血和纤溶指标的检测。结果与非孕妇比较,健康产妇的各种凝血相关时间缩短,血浆纤维蛋白原(Fib)升高;而发生DIC的产妇在产前状态时就有各种凝血时间延长,Fib降低,D-二聚体升高,并随着DIC的发展而发生进行性变化。结论产科DIC的各种凝血与纤溶指标在产前就已发生明显变化,但由于孕妇的高凝状态等因素的干扰,无法正确反映DIC时凝血因子的消耗程度,因此要给予动态监测才能对DIC做出早期诊断。
Objective To explore the clinical significance of the dynamic changes of coagulation and fibrinolysis indicators in diagnosis of DIC in obstetrics. Methods The blood coagulation and fibrinolysis indicators were measured in 50 cases of healthy non-pregnant women, healthy pregnant women （antepartum and labor）, and 50 cases of pregnant women complicated with DIC （antepartum and labor）. Results Compared with those of the non-pregnant women, the healthy pregnant women had shorter coagulation related time and higher level of plasma fibrinogen; whereas the pregnant women complicated with DIC had longer clotting time, lower plasma fibrinogen, and elevated D-dimer at antepartum, and the changes were associated with the development of DIC. Conclusion The coagulation and fihrinolysis indicators have changed at antepartum in pregnant women complicated with DIC, but the change doesn＇t reflect the consumption level of blood coagulation factors due to interference of hypereoagulabale state in pregnant women. Early diagnosis of DIC is depedent on dynamic monitoring of coagulation and fibrinolysis indicators.
出处
《检验医学与临床》
CAS
2009年第2期100-100,102,共2页
Laboratory Medicine and Clinic
关键词
凝血与纤溶
动态观察
弥漫性血管内凝血
D-二聚体
coagulation and fibrinolysis
dynamic observation
disseminated inravascular coagulation
D-dimer
