摘要
目的了解血脂与脑梗死患者颈动脉粥样硬化的关系。方法对344例脑梗死疑似患者进行三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-I(apo A-I)、载脂蛋白B(apo B)、脂蛋白(a)[Lp(a)]检测,同时用计算机断层扫描(CT)、B超检测颈动脉病变。结果344例脑梗死疑似患者中有303例经临床及CT检查诊断为脑梗死,其余41例作为对照组。303例确诊患者中颈动脉管壁内膜-中层厚度(IMT)>0.9 mm或有斑块者206例,占68.0%;其余97例无病变,占32.0%。脑梗死患者LDL-C水平无论有无颈动脉病变均高于对照组(P<0.05)。无脑梗死的颈动脉粥样硬化患者apoA-I水平低于对照组(P<0.05)。结论LDL-C、apo A-I是发生脑梗死和颈动脉硬化病变重要的危险因素和诊疗的观察指标,B超检测颈动脉粥样硬化再结合血脂检查,对于脑血管疾病的预防、早期诊断、指导治疗以及观察疗效具有一定的临床价值。
Objective To explore the relationship between the blood lipid and the carotid atherosclerosis in the patients with cerebral infarction. Methods The levels of triglycerides （ TG）, total cholesterol （ TC ）, high density lipoprotein-cholesterol（ HDL-C ） , low density lipoprotein-cholesterol （ LDL-C ） , apolipoprotein A-I （ apo A-I ） , apolipoprotein B （ apo B ） , lipoprotein （ a ） [ Lp （a） ] in 344 patients with suspect cerebral infarction were determined and the carotid atherosclerosis was detected by computed tomography （CT）and B-uhrasonographic imaging at the same time. Results In 344 suspect patients,there were 303 patients with cerebral infarction well diagnosed by CT and 41 patients as control groups. In 303 patients with cerebral infarction, 206 patients （68.0%） with carotid artery intima-media thickness （IMT） 〉 0.9 mm or with atheromatous plaque and 97 patients （32.0%） without carotid atheroselerosis were found. The levels of LDL-C in patients with cerebral infarction were significantly higher than that in control groups （ P 〈 0.05 ） no matter whether they were with or without carotid atheroselerosis. The level of apo A-I in patients with carotid atherosclerosis but without cerebral infarction was significantly lower than that in control groups （ P 〈 0.05 ）. Conclusions The LDL-C and apo A-I are important risk factors and indexes for the patients with cerebral infarction. The carotid atherosclerosis determination by B-uhrasonography and integration blood lipid determination should be useful and valuable for early diagnosis and observation of treatment result in cerebrovascular diseases.
出处
《检验医学》
CAS
北大核心
2009年第1期37-39,共3页
Laboratory Medicine
关键词
血脂
脑梗死
颈动脉粥样硬化
Blood lipid
Cerebral infarction
Carotid atherosclerosis
