摘要
目的了解嗜麦芽窄食单胞菌Ⅰ类整合子的存在情况以及耐药谱型。方法2006年7月-2007年12月自临床标本分离60株嗜麦芽窄食单胞菌，采用聚合酶链反应法检测分析其基因int Ⅰ、qacE△1-sul 1。药敏试验采用微量肉汤稀释法。结果60株嗜麦芽窄食单胞菌Ⅰ类整合子阳性率为13．33％（8／60），对临床常用抗菌药物敏感率〉80％的仅有米诺环素、复方磺胺甲嗯唑、左氧氟沙星。结论嗜麦芽窄食单胞菌是一种重要的医院感染病原菌，其具多重耐药性，Ⅰ类整合子的存在加快了细菌耐药性的传播。
Objective To investigate the positive rate of class Ⅰ integrons and drug-resistance of Stenotrophomonas maltophilia. Methods Sixty strains of Stenotrophomonas maltophilia were clinically isolated between July, 2006 and December,2007,the genes of int Ⅰ , qaeE△1 sul 1 of these strains were analyzed by PCR and antirnicrobial susceptibility tests were perforrned by micro-broth dilution method. Results The positive rate of class Ⅰ integrons was 13. 33% （8/60）, only 80% Stenotrophomonas maltophilia were sensitive to minocycline, trimethoprimsulfamethoxazole and levofloxacin. Conclusion The Stenotrophomonas maltophilia is an important pathogen in nosocomial infection, which has multiple-drug resistance, and class Ⅰ integrons genes can promote the spread of bacterial resistance.
出处
《中国感染控制杂志》
CAS
2009年第1期33-35,共3页
Chinese Journal of Infection Control
基金
河北省科技厅科技攻关课题(072761546)
关键词
嗜麦芽窄食单胞菌
整合子
Ⅰ类
抗药性
微生物
耐药机制
抗菌药物
Stenotrophomonas rnaltophilia
class Ⅰ integrons
drug resistance, microbial
drug-resistance mechanism
antimicrobial agents
