摘要
目的了解肝移植患者术后嗜麦芽寡养单胞菌感染的分布及耐药情况。方法采用回顾性分析2004年9月-2006年12月从医院肝移植中心490例肝移植术后患者送检的标本中分离到的55株嗜麦芽寡养单胞菌分布及耐药情况。结果呼吸道标本是嗜麦芽寡养单胞菌感染的主要来源,占69.1%,其次为胆汁、导管分泌物和血液;嗜麦芽寡养单胞菌对大多数抗菌药物耐药,敏感性较好的是喹诺酮类、头孢哌酮/舒巴坦,复方新诺明。结论肝移植患者术后嗜麦芽寡养单胞菌感染率为11.2%,嗜麦芽寡养单胞菌的耐药性严重,早期拔出插管和合理使用抗菌药物,可减少肝移植患者术后嗜麦芽寡养单胞菌的感染。
OBJECTIVE To find out the distribution and drug resistance of Stenotrophomonas maltophilia in patients after liver transplantation. METHODS From Dec 2006 to Jan 2004, the distribution and drug resistance of S. maltophilia in 490 patients underwent liver transplantation in the Liver Transplantation Center were restrospectively analyzed. RESULTS There were 38 S. maltophilia strains （69. 1%） detected from respiratory tract samples. The drug sensitivity showed these strains were resistant to commonly used antibiotics, and some drugs whose sensitivity was over 50% included doxycycline, cefoperazone-sulbactam, fluoroquinolones and compound sulfamethoxazole. CONCLUSIONS The incidence of S. rnaltophilia is 11. 2% in patients after liver transplantation. Most of the isolated pathogens are drug resistant. Extubating as early as possible and avoiding long duration of broad spectrum antibiotics administrating are important factors to prevent S. maltophilia infection after liver transplanation.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第11期1629-1631,共3页
Chinese Journal of Nosocomiology
基金
武警总医院课题(2008010,2006017)
关键词
肝移植
嗜麦芽寡养单胞菌
耐药性
Liver transplantation
Stenotrophomonas maltophilia
Resistance
