摘要
由壳聚糖与环氧丙烷制备了取代度为0.46的羟丙基壳聚糖(HCS)。将其配制成水溶液,利用离子凝胶法与多聚磷酸钠(TPP)反应,形成形状规整、粒径在100～300 nm可控的羟丙基壳聚糖纳米微球,以牛血清蛋白(BSA)为模型药物,考察了其缓释效果。结果显示,最大包封率达86%,载药量为46%,在缓释初期2 h内平均释放药量的28%,后期均呈现缓慢释放。
Hydroxypropyl-chitsoan（HCS） with a substitution degree of 0.46 was prepared. Hydroxypropyl-chitosan nanospheres with the particle size of 100 -300 nm were formed when hydroxypropyl-chitosan water solution reacts with sodium polyphosphate based on ion gel method. TEM micrograph reveals that the morphology of hydroxypropyl-chitosan nanospheres was regular. Bovine Serum Albumin （BSA） was taken as the typical drug to determine the controlled release in vitro. The result suggests that the highest encapsulation efficiency and load of BSA reached to 86% and 46% respectively. The HCS nanospheres released 28% of BSA in average within 2 h, and it continuously release the entrapped protein, but with a slower rate.
出处
《应用化学》
CAS
CSCD
北大核心
2009年第2期193-197,共5页
Chinese Journal of Applied Chemistry
基金
江西省自然科学基金(0620071)资助项目
江西省教育厅科技项目(赣教技字[2007]168号)
航空高校科研基金(EA200502138)资
关键词
壳聚糖
羟丙基
纳米微球
牛血清蛋白
缓释
chitosan, hydroxypropyl, nanosphere, Bovine Serum Albumin, controlled release
