摘要
芳香醛与NaHSO3加成得到羟基磺酸盐,加入邻苯二胺或取代邻苯二胺在乙醇中回流反应,空气氧化直接得到2-取代苯并咪唑。在合成的15个化合物中,产率均超过80%。其中化合物2-(4-氯苯基)-6-甲氧基-1H-苯并咪唑尚未见报道。所有产物结构经元素分析、IR、1H NMR分析技术得到确证。合成方法无需任何催化剂,操作简单,条件温和,环境友好。
Several aromatic aldehydes and sodium bisulfite were mixed to prepare hydroxyl sulfonates, which were added to o-phenylenediamine or substituted o-phenylenediamine in refluxing ethanol to afford 2-substituted benzimidazoles through oxidation by air directly. One of the fifteen synthesized compounds, 2-（4-chloro- phyenyl）-6-methoxyl-lH-benzimidazole has not been reported. All the compounds were identified by IR, ^1H NMR spectra and elemental analysis. The method is simple, mild, eco-friendly and requires no catalyst.
出处
《应用化学》
CAS
CSCD
北大核心
2009年第2期130-134,共5页
Chinese Journal of Applied Chemistry
基金
国家重点基础研究发展计划(2003CB716004)资助项目
关键词
芳香醛
邻苯二胺
取代苯并咪唑
合成
aromatic aldehyde,o-phenylenediamine, substituted benzimidazole, synthesis
