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Orexin与发作性睡病的研究进展 被引量：1

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摘要 Orexin是一种由下丘脑外侧区产生的具有多种生理功能的神经肽,在睡眠-觉醒周期的调节中发挥重要作用。研究表明,orexin缺乏或受体功能缺陷是导致发作性睡病的原因之一。因此,orexin替代疗法和orexin受体激动剂可能成为治疗发作性睡病的新手段。
作者 唐吉友 张秀清
机构地区 山东大学附属千佛山医院神经内科
出处 《国际神经病学神经外科学杂志》 2008年第6期500-503,共4页 Journal of International Neurology and Neurosurgery
关键词 OREXIN 受体 发作性睡病
分类号 R742.89 [医药卫生—神经病学与精神病学]
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参考文献24

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同被引文献32

  • 1Fronczek R, Lammers G J, Balesar R, et aL The number of hypothalanlic hypocretin ( orexin ) neurons is not ,affected in Prader-Willi syndrome[J], d Cllh EndocrinolMetab, 2005, 90 ( 9 ) :5466-5470.
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  • 6Diniz Behn C G, Klennan E B, Moctfizuki T, et al. Abnormal sleep/wake dynamics in orexin knockout mice [J]. Sleep, 2010, 33 ( 3 ) :297-306.
  • 7Beuckmann C T, Sinton C M, Williams S C, et al. Expression ofa poly- glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy- cataplex3, in the rat , J Neurosci, 2004, 24 ( 18 ) :4469-4477.
  • 8Willie J T, Chemelli R M. Smton C M, et al. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection ofnon-REM and ILEM sleep regulatory processes [J].Nuron, 2003, 38 ( 5 ) :715-7130.
  • 9Hondo M, Nagai K, Ohno K, et al. Histamine-1 receptor is not required as a downstream ettbctor of orexin-2 receptor in maintenance of basal sleep/wake states [J].Acta Phvsiol, 2010, 198 ( 3 ) :287-294.
  • 10Peltonen H M, Magga J M, Bart G, et al. Involvement of TRPC3 channels in calcium oscillations mediated by OX1 orexin receptors [J]. Biochem Biophvs Res Commun 2009, 385 ( 3 ) :408-412.

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国际神经病学神经外科学杂志
2008年 第6期

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