摘要
目的探讨儿童神经精神性狼疮（NPSLE）的发病有无相关因素或预测指标。方法回顾性分析1990--2006年诊断为SLE的62例中国儿童系统性红斑狼疮（SLE）患者的临床资料，分别比较有NPSLE组和无NPSLE组、早发NPSLE组和晚发NPSLE组、同组患者诊断NPSLE时和诊断SLE时等的临床资料。结果有NPSLE组在诊断SLE时LN存在率、尿检异常率和尿蛋白定量（24h）值明显低于无NPSLE组；早发NPSLE组的平均年龄明显小于晚发NPSLE组，SLE疾病活动指数（SLEDAI）明显高于晚发NPSLE组；晚发NPSLE组在诊断NPSLE时和诊断SLE时临床表现和实验室检查等各项指标差异均无统计学意义。结论在诊断SLE时存在狼疮肾炎（LN）的患者发生NPSLE概率降低；早发NPSLE大多年龄小，疾病活动性高；没有临床指标可以预测NPSLE的发生。
Objective To investigate the relationship between NP involvement and clinical factors and the potential predictors for NPSLE in children. Methods Sixty-two Chinese children with SLE diagnosed between 1990 and 2006 were retrospectively reviewed. Clinical characteristics and potential predictors for NPSLE were analyzed in patients with NP vs those without NP, early-onset NP vs late-onset NP, SLE-onset vs NP-onset in late-onset NP group. Results Ratio of lupus nephritis（LN） at SLE onset was less common in patients with NP disorders than those without NP; the mean age for the early-onset group was significantly younger and the SLEDAI score was higher than those of late-onset group. There was no difference in all the clinical and serological factors for SLE-onset vs NP-onset in the late-onset NPSLE group. Conclusion NP development is negatively associated with renal involvement at SLE diagnosis. Early-onset NPSLE usually happens in young patients with high disease activity scores. There are no clinical factors that can predict the development of NPSLE.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2009年第1期23-26,共4页
Chinese Journal of Rheumatology
关键词
红斑狼疮
系统性
狼疮肾炎
儿童
神经精神症状
Lupus erythematosus, systemic
Lupus nephritis
Child
Neuropsychiatric symptoms
