摘要
目的:观察经导管肝动脉化疗栓塞术(TACE)治疗原发性肝细胞肝癌(HCC)对患者乙肝病毒活动状态及肝功能的影响。方法:动态检测81例乙肝标志物阳性HCC患者TACE术前、术后HBV DNA定量及肝功能变化。结果:81例患者行TACE术后,32例出现HBV激活,激活率为39.5%(32/81);TACE术前HBV DNA定量为(4.2±0.6)×104copies/ml,低于术后(5.8±0.3)×105copies/ml(P<0.05);激活组32例中75%出现明显肝损害,高于非激活组40.8%(P<0.05)。结论:TACE治疗将引起HCC患者HBV激活,可能加重肝功能损害,应值得高度重视。
Objective： To study the hepatitis B virus replication status and liver function in patients undergoing TACE with HCC. Methods：To detect HBV DNA levels and liver function in 81 HBs Ag-positive patients with HCC before and after TACE therapy. Results：Of the 81 HCC patients after TACE, hepatitis B virus reaction occurred in 32（39. 5% ）. HBV DNA quantities was （4. 2 ± 0. 6 ） × 10^4 eopies/ml before TACE compared with （5.8 ± 0. 3 ） × 10^5 copies/ml after TACE （ P 〈 0. 05 ）. The liver function injuried rate in HBV reaction group was 75% compared with 40. 8% in non-reactivation group （ P 〈 0. 05 ）. Conclusion ： TACE therapy in hepatocellular carcinoma can induce activation of hepatitis B virus and may cause liver function deterioration, which merits serious attention.
出处
《临床肿瘤学杂志》
CAS
2008年第12期1096-1098,共3页
Chinese Clinical Oncology
关键词
肝动脉化疗栓塞
肝细胞肝癌
HBV
DNA
Trans-artery chemo-embolization（TACE）
Hepatocellular carcinoma（HCC）
HBV DNA
