摘要
本文研究了柑桔皮提取物对环磷酰胺所引起的小鼠生殖细胞损伤的保护作用。试验考察了小鼠精子畸形,小鼠早期精细胞微核两项指标。两试验结果表明,环磷酰胺后柑桔皮提取物的使用,对降低环磷酰胺所致的小鼠生殖细胞损伤作用不明显,而柑桔皮提取物预防组0.1/kg能显著拮抗环磷酰胺所致的小鼠生殖细胞损伤(P<0.01),而其本身无致突变作用。
In present study, the anti-injure effect of EOF, on incidence of sperm abnormality and meiotic mi-cronuclei of early spermatids in mice induced by cyclophosphamide was investigated. The results indicated that EOF itself was not a mutagen. but significantly inhibited increase of the rate of micronuclei and the sperm abnormality by CP. The rates of sperm abnormality and meiotic micronuclei of early spermatide of EOP before CP using group were lower obviously than those of CP could before EOP using group (P<0. 01). The results suggested that the CP could permeate blood-testis barrier into germ cells of male mice and induced mutation on genetic material.
出处
《中药材》
CAS
CSCD
1998年第2期88-90,共3页
Journal of Chinese Medicinal Materials
