摘要
目的:检测少精子症和/或弱精子症患者空腹血浆同型半胱氨酸(homocysteine,Hcy)水平,并探讨其临床意义。方法:86例少精子症和/或弱精子症患者分为3组:少精子症组(n=21),弱精子症组(n=32),少弱精子症组(n=33);对照组(n=19)为精子密度及活力正常的健康男性精液。分别进行精液常规分析和空腹血浆同型半胱氨酸水平测定。结果:3组患者血浆Hcy水平均显著高于健康对照组(P<0.05),3组患者间血浆Hcy水平无显著性差异(P>0.05)。血浆中Hcy水平与3组患者的a级精子百分率、(a+b)级精子百分率及密度之间均呈负相关(r=-0.303、-0.339、-0.433,P<0.05)。结论:人血浆Hcy水平升高可能会直接或间接地影响精子发生,与少和/或弱精子症密切相关。
Objective： To detect the level of fasting plasma homocysteine （Hcy） in patients with oligospermia and/or asthenospermia and to investigate its clinical significance. Methods ： Semen quality analyses and fasting plasma Hey determination were performed for 86 infertility patients （21 with oligospermia, 32 with asthenospermia and 33 with oligo-asthenospermia） and 19 normal fertile volunteers. The results were compared. Results ： The level of plasma Hcy was significantly higher in the infertility patients than in the normal controls （P 〈 0.05） and negatively correlated with sperm concentration （ r = -0.433, P 〈 0.01 ）, the percentage of grade a sperm （r= -0.303, P 〈 0.05） and the percentage of grade a＋b sperm （r= -0.339, P 〈 0.01）. Conclusion： The increased level of human plasma Hey directly or indirectly affects spermatogenesis and correlates negatively with oligospermia and/or asthenospermia.
出处
《中华男科学杂志》
CAS
CSCD
2008年第12期1112-1114,共3页
National Journal of Andrology
