摘要
目的探讨IgA肾病患者的临床表现和肾脏病理的特点及其相互关系。方法收集62例IgA肾病患者的临床资料及肾脏病理资料并进行统计学分析。结果病理类型中以系膜增生性、局灶节段增生性、局灶节段性硬化症三种最多,共占90.32%。Lee氏病理分级中以Ⅲ、Ⅳ级最多,共82.26%,随着Lee氏病理分级程度的增高。血压、血肌酐、血尿酸、24h尿蛋白量有不同程度的升高趋势(P<0.05或P<0.01)。Katafuchi积分与收缩压、血肌酐、血尿素氮、血尿酸、24h尿蛋白量呈显著正相关(P<0.01)。结论IgA肾病肾脏病变与血压、肾功能、24h尿蛋白量等临床表现之间存在明显的相关关系。
Objective To investigate the relationship between clinical features and renal pathological classification in IgA nephropathy （IgAN）. Methods Clinical features and renal pathological classification in 62 paients with IgAN were collected and analyzed. Results Mesangial proliferative glomerulonephtitis, focal proliferative glomerulonephritis and focal segmental glomerulosclerosis are the most common types（90. 32% ）, Lee＇s pathological grade Ⅲ and Ⅳ are the most common types（ 82.26%）. Blood pressure, serum creatinine, uric acid and 24-hour urinary protein levels increase with Lee＇s pathological grade increasing （P〈0.05 or P 〈0.01）. There is positive correlation between Katafuchi score and systolic blood pressure, serum creatinine, urea nitrogen, uric acid and 24 - hour urinary protein levels （P〈0.01）. Conclusion Renal pathology in IgAN is significantly correlated with clinical features.
出处
《中国微循环》
北大核心
2008年第6期377-379,共3页
Journal of Chinese Microcirculation
关键词
IGA肾病
病理分级
临床表现
IgA nephropathy
Pathological grade
Clinical feature
