摘要
目的通过较大样本的人群血清学筛查,建立各孕周AFP、F-β-HCG的中位数,并探讨高危人群范围。方法对8341例孕14-21+6周孕妇,采用时间分辨荧光免疫系统进行血清标志物检测,通过特殊软件进行风险计算,得出高危孕妇,并对其进行产前诊断。并利用非线性加权回归模型计算并建立各孕周的AFP、F-β-HCG的中位数。结果筛查出唐氏综合征高危485例,筛查阳性率5.81%(485/8341),确诊唐氏患儿8例,假阴性病例1例。建立的各孕周AFP、F-β-HCG的中位数与原始筛查软件内嵌参考值比铰均有显著性差异。经修正后的中位数重新分析,9例唐氏患儿全部检出。结论建立适合各地区人群的唐氏综合征血清学筛查AFP、F-β-HCG的中位数值,对提高了筛查效率很有必要。
Objectives： To determine the medians of AFP and F - 13 - HCG of each week in pregnancy and the scope of high - risk groups via serological screening in a large sample of population. Methods： Serum marker test was performed for a total of 8341 pregnant women in their 14 - 21^ ＋6 weeks of pregnancy using time - resolved immunofluorometric assay system. The results were used for calculating the risks with special software. The high - risk pregnant women were identified, and antenatal diagnoses were made. The medians of AFP and F - β - HCG of each pregnant week were calculated by nonlinear weighted regression. Results： A total of 635 cases of Down＇s syndrome were identified on screening at a positive rate of 7.61% （635/8341）. Eight infants were diagnosed with Down＇s syndrome, with one false negative case. The medians of AFP and F - β - HCG of each pregnant week were significantly different from the imbedded references on the screening software. All the nine cases were detected with the modified medians. Conclu- sion： Multi - center large - sample studies to establish the medians of AFP and F - β- HCG suited for serological screening of Down＇s syndrome in groups in difderent place are necessary for improved screening efficiency.
出处
《中国优生与遗传杂志》
2008年第11期38-39,共2页
Chinese Journal of Birth Health & Heredity
关键词
唐氏综合征
产前筛查
中位数
Down＇s syndrome
Antenatal Screening
Median
