摘要
目的:通过较大样本的人群血清学筛查,探讨中国人群孕早期PAPP-A、Fβ- HCG的中位数,提高唐氏综合征检出率.方法:对3854例9～13周的孕妇,应用时间分辨荧光免疫法进行血清PAPP-A、Fβ-HCG定量检测,同时利用非线性加权回归统计方法建立各孕周PAPP-A、Fβ-HCG的中位数,与筛查软件提供的原始参考值进行比较.结果:筛查出4例唐氏综合征,2例假阴性,新建立的各孕周PAPP-A、Fβ-HCG中位数与原始参考值比较有显著性差异.用修改后的中位数重新分析,6例唐氏综合征患儿全部检出.结论:中国人群血清PAPP-A、Fβ-HCG的中位数偏高.在孕早期筛查唐氏综合征时,需要多中心大样本的研究以建立适合中国人群的PAPP-A、Fβ-HCG中位数,避免出现假阴性,提高筛查效率.
Objective： To investigate the median serum levels of PAPP-A and free β-HCG in the first trimester of pregnancy in ethnic Chinese by screening comparatively large sample. Methods： the levels of maternal serum PAPP-A and free β-HCG were measured with auto time- resolved fluoroimmunoassay system at 9^＋0 to 13^＋6 weeks＇ gestation. The median of PAPP-A and free β-HCG in each gestation week were calculated with weighted nonlinear regression and were compared with the original reference median which offered by the screening soft ware. Results： 4 cases of Down＇s syndrome had been screened out, 2 trisomy 21 missed. While the new established median of PAPP-A and β-HCG in each gestation week had significant differences compared with original reference median. All 6 cases of Down＇s syndrome were completely detected after recalculating with amending median. Conclusion： Ethnic Chinese have a significantly higher median of PAPP-A and free β-HCC. When screening Down＇s syndrome in the first trimester, it is necessary to establish the optimal median of PAPP-A and β-HCG in Chinese population by multicenter research to avoid false negative and improve the screening efficiency.
出处
《生物数学学报》
CSCD
北大核心
2007年第3期554-558,共5页
Journal of Biomathematics
