摘要
目的探索新生儿缺血缺氧性脑病(hypoxic ischemic encephalopathy,HIE)的新的治疗方法,观察脑苷肌肽治疗中、重度新生儿缺氧缺血性脑病(HIE)疗效。方法对中、重度缺氧缺血性脑病在对症、支持及胞二磷胆碱等治疗的基础上将脑苷肌肽注射液6ml加入10%GS20～30ml中静滴,每日1次,7～10天为1个疗程。观察2组患儿在治疗前后新生儿神经行为评分(NBNA)。结果治疗组NBNA≥35分:第7、14天分别为25(48.9%)、38(84.4%)例,对照组16(25%)、33(63.9%)例,2组分别比较差异有显著性(P<0.05)。结论早期应用脑苷肌肽注射液,对HIE有治疗作用,能改善缺氧缺血性脑病患儿的神经行为能力,从而有助于其预后。治疗中未见副作用。
Objective ： A new safety and effective therapeutic method tier hypoxic - ischemic encephalopathy （HIE） was detected. Methods： On the basis of expectant, supporting and Naoganjitai injection treatment of HIE, the eases were given 6ml Naoganjitai injection by intravenous drip after dilution with 10% GS once a day. One course of treatment included seven to ten days. Neonatal behavioral neurological assessment （NBNA） was performed before and after treatment of Naoganjitai injection. Results： NBNA of patients with HIE in treatment group with Naoganjitai injection was distinctively higher than that of the control group. Conclusion ： Early treatment of HIE with Naoganjitai injection could prevent the brain from injury after asphyxia, block the development of HIE, improve the nervous behavior and prognosis in newborn with HIE.
出处
《中国优生与遗传杂志》
2008年第12期84-84,91,共2页
Chinese Journal of Birth Health & Heredity
