摘要
目的探讨ＧＭ１对脑缺血／再灌流的保护作用。动态观察神经节苷脂ＧＭ１对大鼠ＭＣＡＯ／ＩＲ模型细胞外液氨基酸类神经递质的影响。方法采用缺血１ｈ再灌流２ｈ模型，用活体微透析法，检测缺血皮层脑组织细胞外液内氨基酸类神经递质。结果（１）脑缺血后６０ｍｉｎＧｌｕ上升到峰值浓度，随后很快下降，再灌流２ｈ内未见回升；（２）ＧＭ１组各类氨基酸都明显下降。结论ＧＭ１能使包括Ｇｌｕ在内的多种氨基酸明显下降。
Objective To study the protective function of GM 1 in cerebral ischemia and reperfusion and effect of GM 1 on amino acid changes during rat cerebral artery occlusion and reperfusion(MCAO/IR).Methods Using 2hr ischemia/1hr reperfusion suture model,we measured extracellular amino acids collected from ischemic brain cortices by HPLC.Results 1.Glutamate increased rapidly and reached a peak level at 60 minute after ischemia;2.In GM 1 group,all determined amino acids were significantly decreased.Conclusion Our resulsts suggest that the protective function of GM 1 in brain ischemia/reperfusion may be related to the maintenance of membrane integrates of neurons.
出处
《中风与神经疾病杂志》
CSCD
北大核心
1998年第1期3-5,共3页
Journal of Apoplexy and Nervous Diseases
