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顺铂联合紫杉醇方案在局部晚期宫颈鳞癌新辅助化疗中的应用 被引量:10

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摘要 目的评价顺铂联合紫杉醇方案作为新辅助化疗在宫颈鳞癌治疗中的抗肿瘤作用及毒性。方法对2005年7月~2007年7月采用紫杉醇联合铂类药物(TP方案)和5-氟尿嘧啶联合铂类药物(FP方案)以及长春新碱加铂类药物和博莱霉素(VBP方案)化疗方案作为一线药物进行新辅助化疗的局部晚期宫颈鳞癌患者68例进行回顾性分析,其中TP组32例,FP组22例,VBP组14例。所有患者均接受新辅助化疗两疗程,配合后装放疗15~20Gy,然后评价肿瘤治疗效果,再进行手术治疗。结果TP组、FP组、VBP组有效率分别为75.0%、45.5%和42.9%,3组总有效率为58.8%。TP组有效率高于FP组和VBP组(P<0.05)。结论紫杉醇与顺铂联合是一种非常有效的新辅助化疗方案,可有助于更好地控制肿瘤,达到术前治疗的目的。
出处 《南方医科大学学报》 CAS CSCD 北大核心 2008年第11期2072-2074,共3页 Journal of Southern Medical University
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