摘要
观察心脏瓣膜替换术后病人静脉点滴硝普钠（ＳＮＰ）对血小板聚集功能的影响。ＳＮＰ组每分钟静脉点滴１～２μｇ／ｋｇ１５例及对照组１６例（用药除ＳＮＰ外与ＳＮＰ组均相同），采用比浊法测定病人血小板聚集功能。结果显示ＳＮＰ组二磷酸腺苷（ＡＤＰ）、肾上腺素（ＥＰＮ）及胶原（Ｃｏｌ）诱导的血小板聚集功能与对照组相比，均明显降低（Ｐ＜０．０１）。结论：心脏瓣膜替换术后病人应用ＳＮＰ可能有助于预防术后心脏血栓形成及血栓栓塞。手术近期大剂量应用ＳＮＰ或同时应用抗凝及其他抗血小板药物者，应注意术后出血可能性增加。
Aim:To evaluate the effects of sodium nitroprusside (SNP) on platelet aggregation in patients undergoing heart valve replacement.Clinical material and method:Thirty-one patients underwent heart valve replacement.Of whom,15 patients received SNP 1-2μg.kg/min intravenously (SNP group) and the other 16 patients received same administration as SNP group but without SNP (control group).Platelet function was studied and aggregation was induces by adenosine diphosphate (ADP),epinephrine (EPN) and collagen (Coll),respectively.Result:In SNP group,Platelet aggregation was decreased significantly when compared with control group (P<0.01).Conclusion:SNP could decrease platelet aggregation and result in improvement of heart function and decrease incidence of intracardiac thrombosis and thromboembolism after valve replacement.The risk of postoperative bleeding should be considered when using high-dose of SNP or using anticoagulants and other antiplatelet agents during perioperative period.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1998年第1期10-11,共2页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
人工心脏瓣膜
血小板聚集
硝普钠
Platelet aggregation Sodium nitroprusside Heart valve replacement
