摘要
【目的】探讨血管内皮生长因子165(VEGF165)和基质金属蛋白酶2(MMP2)与卵巢癌发生和发展的关系及其意义。【方法】采用免疫组织化学SP染色法,检测正常卵巢(n=10)、良性卵巢囊肿(n=15)、卵巢交界性肿瘤(n=11)、上皮性卵巢癌(n=64)中VEGF165和MMP2表达。【结果】VEGF165及MMP2在正常卵巢、良性卵巢囊肿、卵巢交界性肿瘤及上皮性卵巢癌中的表达逐渐增高,在卵巢癌中的表达水平明显高于正常卵巢和卵巢囊肿(P<0.05)。VEGF165及MMP2的表达随肿瘤的分化降低而增加,在低分化癌中表达明显高于高分化腺癌(P<0.05),且其表达与卵巢癌的临床病理分期及淋巴转移均呈正相关(P<0.05)。【结论】在卵巢上皮性癌中VEGF165及MMP2均与癌的发生和病理生物学行为关系密切,为卵巢癌的诊断提供了进一步的依据;并与肿瘤的恶性程度呈明显的正相关,过度表达预示着预后不良。
[Objective]To explore the role of the expression of VEGF165 and MMP2 in tumor genesis and progression of ovarian cancer.[Methods]The expressions of VEGF165 and MMP2 by using immunohistochemisty method in normal ovary（n=10）,ovarian cyst（n=15）,ovarian borderline tumor（n=11） and epithelial ovarian cancer（n=64） were investigated.The relationship between VEGF165 and MMP2 expressions and clinicalpathological characteristics was evaluated.[Results] The immunostaining scores increased significantly from normal ovary,ovarian cyst and ovarian borderline tumor to epithelial ovarian cancer.The expression levels of VEGF165 and MMP2 were significantly higher in ovarian cancer than those in normal ovary and ovarian cyst（P〈0.05）.The expressions of VEGF165 and MMP2 were significantly correlated with tumor grade,clinico-pathological staging and lymphatic metastasis of endometrial carcinoma（P〈0.05）.[Conclusion]This study shows that VEGF165 and MMP2 are closely associated with tumor genesis and pathobiological behaviors of ovarian cancer,and provides further evidence of the relationship between VEGF165 and MMP2 expressions and ovarian cancer.
出处
《医学临床研究》
CAS
2008年第11期1968-1970,共3页
Journal of Clinical Research
