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氧化应激及其介导的细胞凋亡在糖尿病肾病中的作用 被引量：25

Oxidative stress and oxidative stress-mediated cell apoptosis in diabetic nephropathy
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摘要 氧化应激产生的活性氧簇(ROS)在糖尿病肾病(DN)的发病机制中起重要作用。ROS通过激活线粒体、DNA氧化损伤、NFκ-B及影响基因表达等途径诱导细胞凋亡,促进DN病的发生发展。减少ROS的生成及阻断ROS产生后所激活的细胞凋亡途径可成为治疗DN的新靶点。 Reactive oxygen species （ROS） resulting from oxidative stress plays a significant role in the pathogenesis of diabetic nephropathy. It induces cell apoptosis and accelerates the development and progression of diabetic nephropathy through mitochondrial activation, DNA oxidative injury and influence on gene expression. Reducing ROS formation and blocking the pathway of cell apoptosis activated by ROS may become a new target in the treatment of diabetic nephropathy.
作者 沈莉敏 吴晨光
机构地区 江苏大学附属人民医院内分泌科
出处 《医学研究生学报》 CAS 2008年第11期1222-1225,共4页 Journal of Medical Postgraduates
基金 镇江市科技计划项目(批准号:SH2007030)
关键词 氧化应激 活性氧簇 细胞凋亡 糖尿病肾病 Oxidative stress Reactive oxygen species Apoptosis Diabetic nephropathy
分类号 R587 [医药卫生—内分泌]
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参考文献32

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二级参考文献50

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医学研究生学报
2008年 第11期

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