摘要
目的评价非洛地平缓释片治疗轻、中度原发性高血压患者14周后降压幅度与脉搏波速度的变化。方法符合人选标准患者给予非洛地平缓释片5mg治疗，每日1次，每次1片，共2周；如2周末血压达标（〈140／90mmHg），则继续非洛地平缓释片5mg治疗12周。共治疗14周。所有患者分别在入选时、治疗第2周末和治疗第14周末检测脉搏波传导速度。结果所有受试者经意向治疗分析（ITT分析），第2周末血压平均下降21．4／14．2mmHg（P〈0．01），第14周末血压平均下降24．8／17．5mmHg（P〈0．01），收缩压和舒张压分别下降16．5％和18．4％。血压达标受试者，第2周末血压平均下降22．8／15．1mmHg（P〈0．01），第14周末血压平均下降25．0／17．9mmHg（P〈0．01），收缩压和舒张压分别下降16．7％和18．9％。所有受试者脉搏波速度第2周末相对于基线下降0．58m／s（P〈0．05），第14周末下降0．86m／s（P〈0．05）。血压达标的受试者脉搏波速度第2周末相对于基线下降0．55m／s（P〈0．05），第14周末下降0．86m／s（P〈0．05）。本研究中共发生56例（21．5％）与研究药物相关的不良事件，未发现与研究药物相关的严重不良事件。治疗期间较多见的不良事件为头痛、潮红、头晕。治疗后实验室检查或心电图改变无临床显著差异。结论非洛地平缓释片降压同时可降低颈动脉．股动脉脉搏波传导速度；降压疗效可持续，并可显著降低颈动脉．股动脉脉搏波传导速度，改善大动脉僵硬度。
Objective To evaluate the curative effects of slow releasing felodipine on mild to moderate primary hypertension and its influence on the pulse wave velocity of slow of the patients. Methods 260 patients with mild to moderate primary hypertension, aged 35-79, received slow releasing felodipine with the initial dosage of 5 mg once daily for 2 weeks. By the end of the second week, 222 of the 260 patients with their blood pressure （BP） levels 〈 140/90 mm Hg were treated by the same regimen for 12 weeks. Pulse wave velocity （PWV） was measured before the treatment, and by the ends of the second and fourteenth weeks. Intention to treat analysis （ITT analysis） was adopted. Results After 2-week treatment the systolic BP decreased by 21.4 mm Hg and diastolic BP by 14.2 mm Hg （both P 〈0.01 ）. After14-week treatment, the BP decreased by 24.8/17.5 mm Hg （P 〈0.01 ） , the systolic BP decreased by 16.5% and the diastolic BP decreased by 18.4%. The BP of the patients with their BP levels up to standard decreased by 22.8/ 15.1 mm Hg （P 〈 0.01 ） by the end of the second week and decreased by 25.0/17.9 mm Hg by the end of the 14th weeks. The PWV of all patients decreased by 0.58 m/s after 2-week treatment （P 〈 0.05）and by 0.86 m/s after 14-week treatment（P 〈0.05）. The PWV of those up to standard decreased by 0.55 m/s after 2-week treatment（ P 〈 0.05 ） and by 0.86 m/s after 14-week treatment （ P 〈 0.05 ）. Adverse events were observed in 56 patients （21.5%）, including headache, flush, and dizziness, however, no severe adverse event was found. No significant changes in laboratory examinations and ECG were found after treatment. Conclusion Slow releasing felodipine is effective in treating mild to moderate primary hypertension, with sustained efficacy of lowering blood pressure and PWV.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2008年第42期2962-2965,共4页
National Medical Journal of China
关键词
高血压
非洛地平
脉搏波速度
Hypertension
Felodipine
Pluse wave velocity
