摘要
以水杨酸和乙酸酐为原料,以六氢吡啶为催化剂,合成了乙酰水杨酸,对反应条件进行了优化.结果表明,当水杨酸与乙酸酐物质的量比为1∶3,六氢吡啶为水杨酸质量的17%时,在83℃反应55min,乙酰水杨酸的产率可达88.4%.
Acetyl salicylic acid was synthesized from salicylic acid and acetic anhydride catalysed by piperidine. The expected compound could be obtained in 88.4 % yield after heating of the reaction mixtures （the ratio of salicylic acid and acetic anhydride 1：3.0, the mole ratio of piperidine 17 %, 83 ℃ reaction for 30 min）. It showed that acetyl salicylic acid was synthesized in high yield with the catalysis of piperidine.
出处
《河南科学》
2008年第12期1471-1473,共3页
Henan Science
基金
国家科技攻关项目(2004BA525804)
