摘要
脂联素是脂肪细胞特异分泌的一种脂肪因子,具有抗炎、促进脂肪酸氧化、减轻胰岛素抵抗等作用,在酒精性肝病患者及动物模型中,脂联素水平均下降,提示脂联素在酒精性肝病的发病中可能起重要作用,进一步研究其具体作用将为酒精性肝病的防治提供新的思路。
Adiponeetin is an adipokine secreted exclusively by adipocytes. It acts as an antiinflammatory, eytokine and has the ability to promote fat acid oxidation and reduce insulin resistance. The plasma level of adiponeetin is reduced both in patients and animal models of alcoholic liver disease. This suggests that adiponeetin plays a major role in the pathogenesis of alcoholic liver disease. Further investigation on the role of adiponeetin will provide a new therapeutic target for the prevention and cure of alcoholic liver disease.
出处
《国际内科学杂志》
CAS
2008年第11期672-675,共4页
International Journal of Internal Medicine
关键词
肝病
酒精性
脂联素
胰岛素抵抗
受体
脂联素
Liver disease, alcoholic
Adiponectin
Insulin resistance
Receptors , adiponectin
