摘要
目的分析白大衣高血压(WCH)患者动态脉压(APP)及动态脉压指数(APPI)的特征,探讨WCH对血管硬化的影响。方法WCH患者60例、高血压I级患者60例(高血压组)和血压正常者50名(对照组)入选本研究,测量其诊室血压和动态血压,对各组APP及APPI进行组间比较。结果WCH组和高血压组患者的诊室脉压及脉压指数高于对照组(P<0.01),且WCH组高于高血压组(P<0.01);高血压组患者24 h APP大于WCH组和对照组(P<0.01),WCH组患者的白天动态脉压(dAPP)大于对照组(P<0.01),高血压组患者24 h APPI、白天APPI(dAPPI)和夜间APPI(nAPPI)均大于WCH组和对照组(P<0.01),WCH组24 h APPI、dAPPI和nAPPI亦均大于对照组(P<0.05)。结论WCH不同于正常人群,会对血管造成一定程度的损伤,引起血管硬化,但其危害程度小于高血压,造成的损伤作用白天更明显。
Objective To analyze the characteristics of ambulatory pulse pressure（APP） and ambulatory pulse pressure index（APPI） of patients with white coat hypertension（WCH） and to explore the influence of WCH on vascular sclerosis of patients. Methods Sixty cases of WCH patients（ WCH group） , 60 cases of hypertension grade I patients（ EH group） and 50 normal controls（ control group） were enrolled. The clinical blood pressure and ambulatort blood pressure（ABP） were measured. APP and APPI of the three groups were analyzed. Resuits The clinical pulse pressure and pulse pressure index（PPI） of patients in WCH and EH groups were higher than those of control group, and those indexes in WCH group were higher than EH group（P 〈0.01 ）. Twenty-four hours APP of patients in EH group was higher than that of WCH and control groups（ P 〈0.01 ）, and it had no significant difference between WCH and control groups （P 〉 0. 05 ）. Day APP （dAPP） of patients in WCH group was higher than that of control group（P 〈 0.01 ）. Twenty-four hours APPI, day APPI （dAPPI） and night APPI（nAPPI） of patients in EH group were higher than those of WCH and control groups, and compared with control group, they were higher in WCH group（P 〈0. 01 ）. Conclusion Damaged vascular endothelial function and vascular sclerosis can be induced by WCH, hut the extent of damages induced by WCH is lower than that of EH.
出处
《国际内科学杂志》
CAS
2008年第11期643-645,共3页
International Journal of Internal Medicine
关键词
白大衣高血压
动态脉压
脉压指数
White coat hypertension
Ambulatory pulse pressure
Pulse pressure index
