摘要
目的：观察维拉帕米对缺血性急性肾功能衰竭是否具有保护作用。方法：以维拉帕米（１．０ｍｇ／ｋｇ）灌注切除右肾的成年雄性ＳＤ大鼠之左肾，５ｍｉｎ后夹闭左肾动脉４５ｍｉｎ，对照组则灌注生理盐水。再灌注２４ｈ后，观察左肾血流量（ＬＲＢＦ），尿量（ＵＶ），血尿素氮（ＢＵＮ），血肌酐（Ｃｒ），肌酐清除率（ＣＣｒ），左／右肾重量之比（Ｌ／Ｒ，ｋｗ），肾脏组织学评分（ＨＳＫ），尿中Ｎ－乙酰氨基葡萄糖苷酶（ＮＡＧ）和丙氨酸氨基肽酶（ＡＡＰ）活性的变化。结果：与对照组相比，维拉帕米组之ＬＲＢＦ减少较小，ＢＵＮ、Ｃｒ、Ｌ／Ｒ（ｋｗ）、ＨＳＫ较低，ＮＡＧ和ＡＡＰ活性较低，而ＣＣｒ较高。结论：维拉帕米对缺血性急性肾功能衰竭确实具有一定的保护作用。
Purpose To observe whether verapamil provides the protective effect on the ischemic acute renal failure. Methods The left kidneys of the right nephrectomized adult male Sprague Dawley rats were perfused with verapamil(1 0 m/kg) five minutes prior to clamping the left renal artery for 45 minutes, while the control group was perfused with saline. Twenty four hours after reperfusion, changes in left renal blood flow(LRBF), urine volume(UV), blood urea nitrogen(BUN), serum creatinine(Cr), creatinine clearance(CCr), left/right kidney weight(L/R kw), histologic score of kidney(HSK), activities of urinary N acetyl glucosaminidase(NAG) and alanine aminopeptidase(AAP) were observed. Results Compared to the control animals, verapamil treated rats had a less reduction of LRBF, a lower BUN, Cr, L/R kw and HSK, a lower activities of NAG and AAP, and a higher CCr. Conclusions Verapamil does provide a certain degree of protection from ischemic acute renal failure.
出处
《临床与实验病理学杂志》
CAS
CSCD
1997年第3期259-261,I023,共4页
Chinese Journal of Clinical and Experimental Pathology
