摘要
目的：揭示乙型肝炎肝内血管阻塞在肝硬变发展中的作用。方法：对３５０例不同类型的肝硬变标本进行了ＨＥ、组化、免疫组化及超微结构的观察。结果：（１）肝内血管阻塞性病变是乙型肝炎肝硬变的组织病理学特征，有血栓、炎性栓塞、栓塞性静脉炎、血管闭塞性纤维化等表现；（２）血管阻塞性损伤能引起血管、胆管及弹力纤维增生；（３）血管阻塞的大小与肝实质变性坏死密切相关，严重者可引起肝梗塞；（４）血管阻塞－血管纤维化是构成纤维带的主要原因。结论：上述改变对肝纤维化及肝硬变病理发生起重要作用。
Purpose To reveal the role of vascular obstruction in the pathogenesis of liver cirrhosis of hepatitis B. Methods We studied the liver biopsies from 350 patients with liver cirrhosis of different types by HE, histochemical, immunohistochemical and ulstrastructuric analysis. Results (1) The intrahepatic vascular obstruction was a histopathological characteristic of liver cirrhosis of hepatitis B, there were different expression of thromb; inflammatory thrombosis, thrombophlebitis and obliterative fibrosis in the liver venous; (2) The obliterative lesions can cause the proliferations of venous, bile ducts and elastic fiber; (3) There were close relation between the size of vascular obstruction and hepatocellular degenerative necrosis, and severe obstruction in the larger vasculs may cause a liver infarction; (4) The vasculer obstruction to cause fibrosis were primary etiology of constitution of fibrous septation. Conclusions All of these changes may play an important role in the pathogenesis of liver fibrosis and cirrhosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
1997年第3期206-208,I019,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
血管阻塞
乙型肝炎
肝硬变
Ci病
vasculer obstruction
hepatitis B
liver cirrhosis
