摘要
目的:观察疏肝活血法对进展期白癫风患者血浆中β-内啡肽(β-EP)、神经肽Y(NPY)及降钙素基因相关肽(CGRP)水平的影响。方法:将100例进展期白癫风患者随机分为2组,治疗组51例予疏肝活血中药煎剂内服配合消斑酊外涂治疗,对照组49例单纯外用消斑酊治疗。采用放射免疫法测定2组治疗前后血浆中β-EP、NPY及CGRP含量。结果:2组治疗前血浆中β-EP、NPY及CGRP含量比较,差异无显著性意义(P>0.05)。治疗组治疗前后血浆中β-EP、NPY含量比较,差异有显著性意义(P<0.05);CGRP含量比较,差异无显著性意义(P>0.05)。对照组治疗前后血浆中β-EP、NPY及CGRP含量比较,差异均无显著性意义(P>0.05)。结论:疏肝活血法治疗进展期白癫风能够显著降低患者血浆中β-EP、NPY含量,对CGRP无显著影响。
Objective:To observe the effect of liver-soothing and blood-activating therapy on the plasma levels ofβ-endorphin(β-EP), neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP).Meth- ods:One hundred vitiligo patients at progressive stage were randomized into 2 groups:the treatment group received oral use of decoction of liver-soothing and blood-activating herbs and external application of Xiaoban Tincture,and the control group received external application of Xiaoban Tincture only.The plasma levels ofβ-EP,NPY and CGRP were detected with radioilmmunoas- say.Results:The differences of plasma levels ofβ-EP,NPY and CGRP were insignificant between the two groups before treatment (P>0.05).The differences ofβ-EP and NPY levels before and after treatment was significant in the treatment group(P<0.05),while the difference of CGRP was insignifi- cant (P>0.05).Plasma levels ofβ-EP,NPY and CGRP in the control group did not differ from those betore treatment (P>0.05).Conalusion: Liver-soothing and blood-activating therapy is effective on decreasing plasma levels ofβ-EP and NPY,while has no effect on CGRP in vitiligo patients at progressive stage.
出处
《新中医》
CAS
北大核心
2008年第12期36-37,共2页
New Chinese Medicine
