氯诺昔康预先镇痛对妇科患者术后芬太尼镇痛的影响被引量：1

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摘要目的评价氯诺昔康预先镇痛对妇科术后患者自控静脉镇痛（PCIA）芬太尼用量的影响。方法60例ASAⅠ～Ⅱ级择期行开腹手术患者,随机分成观察组和对照组各30例。观察组于手术切皮前及关腹时分别静注氯诺昔康8 mg。2组术毕均用芬太尼PCIA,镇痛配方为芬太尼10 mg/L、托烷司琼5 mg,以生理盐水稀释至100 mL,负荷剂量芬太尼1μg/kg,背景输注2 mL/h,PCA每次1 mL,锁定时间10 min。镇痛期间定时行视觉模拟镇痛评分（VAS）。结果2组患者镇痛效果接近,VAS无显著性差异（P〉0.05）;观察组24 h内芬太尼用药量明显少于对照组（P〈0.05）。结论氯诺昔康预先镇痛能明显减少PCIA芬太尼用药量及不良反应。

作者丁叁强杨丹娜彭皓琰陈仲群

机构地区汕头大学医学院第一附属医院

出处《现代中西医结合杂志》 CAS 2008年第35期5507-5508,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine

关键词氯诺昔康芬太尼预先镇痛患者自控镇痛

分类号 R614.3 [医药卫生—麻醉学]

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参考文献6

1Detlef ER,Morten A,Dietmars. A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery[J ]. Anesth Analg, 1998,86 : 1045 - 1050
2于广祥,龚志毅,秦晓涛,郭向阳,叶铁虎,罗爱伦.氯诺昔康及曲马多用于妇科剖腹手术后病人自控镇痛的临床比较研究[J].临床麻醉学杂志,2001,17(9):478-481. 被引量：30
3何非方,祝继洪,方向明.氯诺昔康超前镇痛在腹腔镜胆囊切除术术后镇痛中的应用[J].中国航天医药杂志,2002,4(6):4-6. 被引量：13
4抗燕南,庄心良,蒋豪,等.当代麻醉[M].上海:上海科学技术出版社,2002:303-304
5Moote C. Efficacy of non-steroidal anti-flammatory drugs in the management of postoperative pain [ J ]. Drugs, 1992,44 (Suppl5) : 14 - 30
6王忠云,黄亚辉,钱燕宁.氯诺昔康对胃癌患者术后曲马多镇痛的影响[J].临床麻醉学杂志,2003,19(10):604-606. 被引量：36

二级参考文献14

1[1]Pruss TP,Radhofer Welte S,Forrest JB, et al.Overview of the phar-macological properties,pharmacokinetics and animal safety assess-ment of lornoxicam.Postgrad Med J,1990,66(Suppl4):18-21
2[2]V.L. Wills,D.R.Hunt. Pain after laparoscopic cholecystectomy. British Journal of Surgery,2000,87,273-284
3[4]Code W.Canadian Journal of Anaesthesia,1993,40:401-405
4[5]Berg J,Christoph T,Senel AC,et al.Isoenzyme-specific cycloxyge nase inhibitors:a whole cell assay system using the human monocytic cell line Mono Mac 6.J Pharmacol Toxicol Methods,1997,37: 179-186
5Skjodt NM, Davies NM. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam. Clin Pharmacokinet,1998,34: 421-428.
6Pruss TP, Stroissnig H, Radhofer-Welte S, et al. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam. Postgrad Med J,1990,66(Suppl 4) : 18-21.
7Kehlet H,Werner M, Perkins F. Balanced analgesia. Whatis it and what are its advantages in postoperative pain?Drugs, 1999,58 : 793-797.
8McCormack K. Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain, 1994,59 : 6-43.
9Kullich W,Klein G. Influence of the nonsteroidal anti-inflammatory drug lornoxicam on the secretion of the endogenos opiatc peptides dynorphin and β-endorphin. Aktuel Rheumatol, 1992,17 : 128-132.
10Code W. NASIDs and balanced analgesia. Can J Anaesth, 1993,40 : 401-405.