摘要
应用LSAB免疫组织化学方法研究67例胃癌标本中p53和c－myc的表达与多药耐药性（MDR）的关系。结果显示本组胃癌中p53阳性32例，阳性率47．8％；c－myc阳性37例，阳性率552％；P－gp阳性39例，阳性率58．2％。p53的异常表达与mdr-1基因表达呈显著正相关（r=0.37，P＜0．05），而c－myc和mdr－1的表达未见明显相关。提示p53异常表达可增强mdr－1基因的表达，从而使胃癌细胞获得MDR类型。
By using immunohistochemical methods, the correlation of the expression of p53 and c-myc protein andmulti-drug resistance (MDR) in 67 cases of gastric cancer was studied. The results showed that 32 (47. 8 % ) casesof gastric cancer were positive of p53, 37 (55. 2 % )cases of gastric cancer were positive of c-myc, 39 (58. 2 % ) ofP-glycoprotein (P-gp). A significant correlation was found between p53 overexpression and mdr-1 gene expression(r=O0 37, P＜0.05). Meanwhile,a non-significant correlation between the expression of c-myc and that of mdr-1was seen. It is suggested that p53 overexpression might increase the expression of mdr-1 gene, so gastric cancerproduces MDR.
出处
《诊断病理学杂志》
CSCD
1997年第2期88-90,共3页
Chinese Journal of Diagnostic Pathology
关键词
胃肿瘤
基因表达
多药耐药性
免疫组化
Gastric neoplasm Gene expression Multi-drug resistance Immunohistochemistry
