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免疫干预联合骨髓干细胞移植治疗早发1型糖尿病的前景 被引量：2

Prospects of immunologic intervention combined with bone marrow stem cell transplantation for treatment of early-onset type 1 diabetes
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摘要 1型糖尿病是由于胰岛β细胞进行性自身免疫性破坏所引起的，其治疗需要自身免疫性反应的逆转、胰岛β细胞的再生和功能恢复。适度的免疫抑制剂治疗早发1型糖尿病可阻止胰岛β细胞进一步损失、减少胰岛素的使用，但不能阻止并发症的恶化。最近许多研究报道，免疫干预联合骨髓干细胞移植可维持较长的胰岛素非依赖时间，然而其能有效治疗早发1型糖尿病的机制尚未清楚。 Type 1 diabetes is an autoimmune disease resuhing in the destruction of insulin-secreting β cells. Treatment of type 1 diabetes may require both reversal of autoimmunity and regeneration of islet β cells. Moderate immunosuppression in newly diagnosed type 1 diabetes can prevent further loss of insulin production and thus reduce the need of insulin,but can not prevent the deterioration of diabetic comphcations. Recent studies reported a comparatively long time of insulin-independent period after immunological intervention combined with bone marrow stem cell transplantation, yet the underlying mechanisms are still unknown.
作者 杨军 陈曦 宁光
机构地区 上海交通大学医学院附属瑞金医院外科 上海交通大学医学院附属瑞金医院内分泌代谢科
出处 《国际内分泌代谢杂志》 2008年第6期403-406,共4页 International Journal of Endocrinology and Metabolism
关键词 骨髓 干细胞移植 免疫干预 1型糖尿病 Bone marrow Stem cell transplantation Immune intervention Type 1 diabetes mellitus
分类号 R587 [医药卫生—内分泌]
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参考文献21

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同被引文献23

  • 1张传仓,朱为国,封志纯.自体骨髓干细胞移植治疗1型糖尿病的初步研究[J].广东医学,2004,25(12):1398-1399. 被引量：10
  • 2洪天配.胰腺干细胞研究的现状与展望[J].世界华人消化杂志,2005,13(3):286-289. 被引量：6
  • 3陈春华,秦莹.胚胎干细胞定向分化为胰岛素分泌细胞的研究进展[J].国际生物医学工程杂志,2006,29(2):96-100. 被引量：8
  • 4Madsen O D. Stem cells and diabetes treatment [J]. APMIS, 2005,113 ( 11- 12) :858-875.
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  • 6Lanus A,Holz G G,Theise N D,et al. In vivo derivation of glucose competent pancreatic endocrine cells from bone marrow without evidence of cell fusion [J]. J Clinical Investigat, 2003,111 (6) : 843-850.
  • 7Hess D,Li L,Martin M,et al. Bone marrow-derived stem cells initiate pancreatic regeneration [ J ]. Nature Biotechnology, 2003,21(7) :763-770.
  • 8Kojima H, Fujimiya M, Matsumura K, et al. Extrapancreatic insulin-producing cells in multiple organs in diabetes [J]. Proc Nat Acad USA, 2004,101 (8) : 2458-2463.
  • 9Mathews V, Hanson P T, Ford E, et al. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury [J].Diabetes, 2004,S3 (1):91-98.
  • 10Burt R K, Oyama Y,Traynor A, et al. Hematopoietic stem cell therapy for 1 diabetes : induction of tolerance and islet cell neogenesis [J]. Autoimmun Rev, 2002,1(3) : 133-138.

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国际内分泌代谢杂志
2008年 第6期

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