肝细胞癌血清学诊断研究进展
Serological research in diagnosing hepatocellular carcinoma
摘要
肝细胞癌(HCC)的早期、正确诊断仍是当前研究的热点和难点。以甲胎蛋白(AFP)为代表的血清肿瘤标志物检测结合影像学及病理学检查已成为肝癌早期诊断的重要手段之一,现就其最新进展作一简述。
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2008年第11期875-877,共3页
Chinese Journal of Hepatology
关键词
癌
肝细胞
血清学试验
诊断
Carcinoma, hepatocellular
Serologic tests
Diagnosis
参考文献29
-
1Li D, Mallory T, Satomura S. AFP-L3: a new generation of tumor marker for hepatocellular carcinoma. Clin Chim Acta, 2001, 313: 15-19.
-
2Tateishi R, Shiina S, Yoshida H, et al. Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers. Hepatology, 2006, 44: 1518-1527.
-
3Marrero JA, Su GL, Wei W, et al. Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients. Hepatology, 2003, 37: 1114-1121.
-
4Nakamura S, Nouso K, Sakaguchi K, et al. Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size. Am J Gastroenterol, 2006, 101: 2038-2043.
-
5Morford LA, Davis C, Jin L, et al. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2. Hepatology, 2007, 46: 1541-1547.
-
6Nakatsura T, Yoshitake Y, Senju S, et al. Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochem Biophys Res Commun, 2003, 306: 16-25.
-
7Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology, 2007, 45: 725-734.
-
8Llovet JM, Chen Y, Wurmbach E, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology, 2006, 131: 1758-1767.
-
9Giannelli G, Marinosci F, Trerotoli P, et al. SCCA antigen com- bined with alpha-fetoprotein as serologic markers of HCC. Int J Cancer, 2005, 117: 506-509.
-
10Oh BK, Kim YJ, Park YN, et al. Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis. Am J Gastroenterol, 2006, 101: 831-838.
二级参考文献4
-
1邹黎,姚登福,孟宪镛.TGF-β1基因多态性、癌变机制及临床价值的研究进展[J].胃肠病学和肝病学杂志,2005,14(6):649-653. 被引量:7
-
2Guo-Zhong Ji,Xue-Hao Wang,Lin Miao,Zheng Liu,Ping Zhang,Fa-Ming Zhang,Jian-Bing Yang.Role of transforming growth factor-beta1-smad signal transduction pathway in patients with hepatocellular carcinoma[J].World Journal of Gastroenterology,2006,12(4):644-648. 被引量:26
-
3姚登福,蒋道荣,吴信华,朱云松,黄介飞,孟宪镛.γ-谷氨酰转移酶及同工酶对肝细胞癌变的监测作用[J].中华肝脏病杂志,2000,8(1):30-32. 被引量:30
-
4杨秉辉,夏景林.原发性肝癌的临床诊断与分期标准[J].中华肝脏病杂志,2001,9(6):324-324. 被引量:1025
共引文献12
-
1姚登福,姜华.基因标志物在肝癌诊断中的临床价值[J].中华肝脏病杂志,2007,15(8):609-611. 被引量:2
-
2胡冬,李军锋,周育森.肝细胞癌早期诊断血清标记物的研究进展[J].中国卫生检验杂志,2008,18(9):1936-1939. 被引量:7
-
3Asmaa I Gomaa,Shahid A Khan,Edward LS Leen,Imam Waked,Simon D Taylor-Robinson.Diagnosis of hepatocellular carcinoma[J].World Journal of Gastroenterology,2009,15(11):1301-1314. 被引量:44
-
4曾庆磊,付素伟,刘娜,徐光华.肝细胞癌血清标志物的研究进展[J].延安大学学报(医学科学版),2010,8(1):15-17.
-
5邵渊,王作仁,李峰.转化生长因子-β_1联合甲胎蛋白异质体二联检测对原发性肝癌诊断的意义[J].现代肿瘤医学,2010,18(10):2009-2012. 被引量:2
-
6高姗,杨万水,高静,王静,项永兵.原发性肝癌的分子流行病学研究进展[J].中国肿瘤,2012,21(2):136-144. 被引量:30
-
7潘冬香,仇小强.细胞因子及受体基因表达与肝癌关系研究进展[J].中国公共卫生,2012,28(11):1527-1530. 被引量:1
-
8严寒,张建平.上皮细胞间充质转分化在肝细胞癌转移中的作用机制研究进展[J].中华外科杂志,2014,52(4):302-305.
-
9李重阳,杨亚飞,赵文成,俞诗源.母鼠注射麻黄素再灌胃中药混合液对仔鼠肝组织结构和抗氧化酶活性的影响[J].解剖学报,2016,47(3):368-373.
-
10满沐苒,周旭林,刘清华.原发性肝癌肿瘤标志物研究进展[J].转化医学电子杂志,2018,5(11):61-66. 被引量:3
-
1霍彩鸿.血清AFP、CA125、CA199和CEA联合检测在原发性肝癌诊断中的价值[J].肿瘤研究与临床,2008,20(6):385-386. 被引量:6
-
2王宇,孙福霞,王超,肖辉,田霖丽,金德均.喉鳞癌患者血清中内皮抑素水平对喉鳞癌诊断价值的研究[J].现代生物医学进展,2008,8(10):1903-1904.
-
3张学兰.血清肿瘤标志物对结直肠癌诊断价值的研究[J].中国基层医药,2014,21(13):1931-1932. 被引量:3
-
4卢宏霞,高峻.血清肿瘤标志物检测对结直肠癌患者病情监测的临床意义[J].肿瘤研究与临床,2014,26(2):126-128. 被引量:10
-
5崔婷婷,曹建彪,郭汉斌,杜囚鹏,马丽.血清肿瘤相关性胰蛋白酶原2检测在胰腺癌初筛中的意义[J].医学综述,2011,17(7):1092-1094. 被引量:4
-
6黄敬泽,王健,张闿珍.2型糖尿病人血清肿瘤坏死因子的变化[J].免疫学杂志,1999,15(4):256-257. 被引量:6
-
7汪善兵,刘佳培,雷开键,贾钰铭.胰腺癌患者血浆中miRNAs异常高表达与临床特征相关性的研究[J].肿瘤,2015,35(8):905-910. 被引量:7
-
8徐爱晖,尹岩伟,陈飞虎.肺癌患者血清内皮抑素水平对肺癌早期诊断价值的研究[J].中华医学杂志,2006,86(27):1916-1918. 被引量:13
-
9孙苏平,金冶宁,魏怡,董昭.鼻咽癌患者放疗前后血清转化生长因子β1改变与疗效关系研究[J].肿瘤防治杂志,2004,11(4):358-360.
-
10黄学梅,易玲,蒋蓉蓉,李莲群,刘预,吴立翔.血清β_2-微球蛋白检测在恶性肿瘤诊断中的临床应用[J].第三军医大学学报,2010,32(15):1680-1681. 被引量:8