摘要
目的探讨早期关节软骨退变在3．0TMR扩散加权成像（DWI）上的表现及其价值。方法选用山羊20只，20个左侧膝关节腔内注射10ml木瓜蛋白酶溶液（5U），建立早期关节软骨退变动物模型（试验组），20个右侧膝关节作为正常对照组，并在注药前及注药后24h行双侧膝关节常规MRI及DWI。测量膝关节软骨各个感兴趣区的表观扩散系数（ADC）值，比较各组间的差异。并取关节软骨组织作蛋白多糖含量测定和组织病理学检查。对骨性关节炎软骨病变组患者的100个膝关节和正常对照组20个膝关节行常规MRI及DWI，测量膝关节软骨各个感兴趣区的ADC值，比较各组问的差异。对所获数据进行配对t检验分析。结果羊正常对照组关节软骨ADC均值（ADCav）为（14．2±2．3）×10^-4mm^2／s，膝关节兴趣区早期退变关节软骨ADCav为（17．5±4．2）×10^-4mm^2／s，早期退变关节软骨组的ADC值明显高于对照组，两组间差异有统计学意义（t=2．709；P=0．016）。羊膝关节软骨蛋白多糖含量变化：对照组关节软骨蛋白多糖含量平均为4．22×10^6μg／k，木瓜蛋白酶注射后24h试验组关节软骨蛋白多糖含量降低至0．82×10^6μg∥kg，试验组与正常对照组比较，差异有统计学意义（t=2．705，P=0．018）。对照组人膝关节软骨ADCav为（7．6±2．2）×10^-4mm^2／s，骨性关节炎软骨病变组人膝关节软骨ADCav为（10．3±4．2）×10^-4mm^2／s。人骨性关节炎软骨病变组膝关节软骨的ADCav值明显高于正常组，差异有统计学意义（t=2．609；P=0．014）。结论MRDWI能发现常规MRI序列软骨信号尚未改变的更早期关节软骨退变。
Objective To study the appearance of MR diffusion weighted imaging in early stages of cartilage degeneration and to detect its values. Methods In 20 goat left knees, intra- articular injection of 5 units of papain was performed causing a loss of cartilage proteoglyean. Twenty right knees were used as control group. MR diffusion weighted imaging was performed at 24 hours after intra-articular injection of papain. ADC of each part of articular cartilage was measured and compared with each other. The proteoglycan content was measured biochemically and histochemically. Routine MRI and DWI were performed in 100 patients with osteoarthritis and 20 healthy people. The ADC of each interested part of articular cartilage was measured and compared with each other. Results In experimental control group, the ADCav of articular cartilage was （ 14. 2 ± 2. 3 ） ×10^-4mm^2/s. In early stages of cartilage degeneration group, the ADCav of articular cartilage was （ 17.5 ± 4.2） ×10^-4mm^2/s. The ADCav of the control group was lower than that of the early stages of cartilage degeneration group （ t = 2. 709 ; P = 0. 016 ） . The proteloglycan content of articular cartilage was 4. 22 ± 106 μg/kg in control group, and 0.82 ± 106 μg/kg in experimental group at 24 hours after injection of papain. The difference between control group and experimental group was significant （t = 2. 705,P = 0.018）. In healthy people, the ADCav of articular cartilage was （7.6 ± 2. 2） ×10^-4mm^2/s. In osteoarthritis group, the ADCav of articular cartilage was （ 10. 3± 4. 2 ）×10^-4mm^2/s. The ADCav in the healthy group was significantly lower than that in the osteoarthritis group（t =2. 609,P =0. 014）. Conclusion DWI is an useful method in detecting early stages of cartilage degeneration which can not be showed on routine sequences.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2008年第11期1205-1209,共5页
Chinese Journal of Radiology
关键词
软骨疾病
膝关节
磁共振成像
弥散
Cartilage diseases
Knee joint
Diffusion magnetic resonance imaging
